Deletion of a Rare Fungal PKS CgPKS11 Promotes Chaetoglobosin A Biosynthesis, Yet Defers the Growth and Development of

Chaetomium globosum chaetoglobosin A chaetoglocin A polyketide synthases secondary metabolites sporulation

Journal

Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827

Informations de publication

Date de publication:
13 Sep 2021
Historique:
received: 03 07 2021
revised: 07 09 2021
accepted: 09 09 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 29 9 2021
Statut: epublish

Résumé

We previously reported that chaetoglobosin A (ChA) exhibits a great potential in the biocontrol of nematodes and pathogenic fungi. To improve the production of ChA, a CRISPR-Cas9 system was created and applied for eliminating potential competitive polyketide products. One of the polyketide synthase encoding genes,

Identifiants

pubmed: 34575788
pii: jof7090750
doi: 10.3390/jof7090750
pmc: PMC8471558
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : the National Science Foundation of China
ID : 81871629

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Auteurs

Biyun Xiang (B)

Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Xiaoran Hao (X)

National Experimental Teaching Demonstrating Center, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Qiaohong Xie (Q)

Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Xiamen No.1 High School of Fujian, Xiamen 361000, China.

Guangya Shen (G)

Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Yanjie Liu (Y)

Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Xudong Zhu (X)

Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Classifications MeSH