Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases.
antiplatelet
clopidogrel
human drug metabolites
prasugrel
thienopyridine
unspecific peroxygenase
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
13 Sep 2021
13 Sep 2021
Historique:
received:
27
08
2021
revised:
10
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450-dependent oxidation via sulfenic acids to the active thiol metabolites. These metabolites are the active compounds that inhibit the platelet P2Y
Identifiants
pubmed: 34575790
pii: jof7090752
doi: 10.3390/jof7090752
pmc: PMC8470877
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 031B0831
Organisme : Brandenburger Staatsministerium für Wissenschaft, Forschung und Kultur
ID : 22-F241-03-FhG/005/001
Organisme : Brandenburger Staatsministerium für Wissenschaft, Forschung und Kultur
ID : INST 263/88-1 LAGG
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