Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD
Adipose Tissue
/ metabolism
Animals
Benzhydryl Compounds
/ adverse effects
Disease Models, Animal
Drinking Water
/ analysis
Environmental Exposure
/ adverse effects
Female
Health Impact Assessment
Immunohistochemistry
Inflammation
/ etiology
Lactation
/ drug effects
Liver
/ drug effects
NAD
/ metabolism
Oxidative Stress
Phenols
/ adverse effects
Pregnancy
Rats
Sirtuin 1
/ metabolism
Water Pollutants, Chemical
/ administration & dosage
Weaning
BPA
Sirt1
Sirt1-AS LncRNA
cerebral ventricles
epigenetics
inflammation
liver
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Sep 2021
07 Sep 2021
Historique:
received:
08
08
2021
revised:
23
08
2021
accepted:
01
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Bisphenol A (BPA) is largely used as a monomer in some types of plastics. It accumulates in tissues and fluids and is able to bypass the placental barrier, affecting various organs and systems. Due to huge developmental processes, children, foetuses, and neonates could be more sensitive to BPA-induced toxicity. To investigate the multi-systemic effects of chronic exposure to a low BPA dose (100 μg/L), pregnant Wistar rats were exposed to BPA in drinking water during gestation and lactation. At weaning, newborn rats received the same treatments as dams until sex maturation. Free and conjugated BPA levels were measured in plasma and adipose tissue; the size of cerebral ventricles was analysed in the brain; morpho-functional and molecular analyses were carried out in the liver with a focus on the expression of inflammatory cytokines and Sirtuin 1 (Sirt1). Higher BPA levels were found in plasma and adipose tissue from BPA treated pups (17 PND) but not in weaned animals. Lateral cerebral ventricles were significantly enlarged in lactating and weaned BPA-exposed animals. In addition, apart from microvesicular steatosis, liver morphology did not exhibit any statistically significant difference for morphological signs of inflammation, hypertrophy, or macrovesicular steatosis, but the expression of inflammatory cytokines, Sirt1, its natural antisense long non-coding RNA (
Identifiants
pubmed: 34575829
pii: ijms22189666
doi: 10.3390/ijms22189666
pmc: PMC8467074
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Drinking Water
0
Phenols
0
Water Pollutants, Chemical
0
NAD
0U46U6E8UK
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2010-2011 to RM
Organisme : Università degli Studi di Napoli Parthenope
ID : Ricerca locale 2017 to RM
Références
Int J Cardiol. 2015;189:30-44
pubmed: 25889431
Mol Cell Endocrinol. 2009 May 25;304(1-2):49-54
pubmed: 19433247
J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):27-34
pubmed: 21605673
Reprod Toxicol. 2010 Aug;30(1):131-7
pubmed: 20214975
J Environ Public Health. 2012;2012:185731
pubmed: 22253637
Biochim Biophys Acta. 2010 Aug;1804(8):1666-75
pubmed: 19879981
Aging (Albany NY). 2020 Mar 6;12(5):4322-4336
pubmed: 32139663
Sci Rep. 2020 Jul 23;10(1):12250
pubmed: 32704131
Environ Health Perspect. 2015 Jul;123(7):643-50
pubmed: 25775505
Handb Clin Neurol. 2017;146:21-32
pubmed: 29110772
J Leukoc Biol. 2018 Mar;103(3):509-524
pubmed: 29389023
Chemosphere. 2018 Oct;209:508-516
pubmed: 29940534
Oncol Rep. 2015 Nov;34(5):2343-50
pubmed: 26324025
Neuroimage Clin. 2017 May 28;15:483-493
pubmed: 28649491
Endocr Metab Immune Disord Drug Targets. 2019;19(5):594-604
pubmed: 30621569
Sci Rep. 2018 Feb 13;8(1):2961
pubmed: 29440646
Apoptosis. 2013 Jun;18(6):689-701
pubmed: 23479127
Sci Total Environ. 2019 Jun 10;668:797-805
pubmed: 30870748
Int J Environ Res Public Health. 2021 Jan 30;18(3):
pubmed: 33573212
Health Promot Chronic Dis Prev Can. 2017 Dec;37(12):403-412
pubmed: 29236378
Food Chem Toxicol. 2018 Apr;114:98-107
pubmed: 29448092
Biotechnol Adv. 2018 Jan - Feb;36(1):311-327
pubmed: 29229539
Acta Neuropathol. 2018 Mar;135(3):337-361
pubmed: 29368213
Environ Health Perspect. 2008 Jan;116(1):39-44
pubmed: 18197297
Fundam Clin Pharmacol. 2017 Dec;31(6):594-609
pubmed: 28622415
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93
pubmed: 19549853
Hum Mol Genet. 2014 Sep 15;23(R1):R54-63
pubmed: 24838284
Mol Cell Endocrinol. 2018 Nov 5;475:74-91
pubmed: 29481862
Sci Rep. 2016 Aug 09;6:31331
pubmed: 27502578
Dose Response. 2015 Jun 17;13(2):1559325815590394
pubmed: 26672480
Front Endocrinol (Lausanne). 2018 Oct 15;9:614
pubmed: 30374331
EFSA J. 2016;14(10):e04580
pubmed: 31024636
Rev Endocr Metab Disord. 2015 Dec;16(4):299-309
pubmed: 26820262
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:90-4
pubmed: 22580014
Environ Health Perspect. 2008 Dec;116(12):1642-7
pubmed: 19079714
Sci Rep. 2016 Feb 23;6:21865
pubmed: 26902620
Toxicol In Vitro. 2012 Aug;26(5):709-17
pubmed: 22515966
FASEB J. 2020 Jan;34(1):350-364
pubmed: 31914699
Reprod Toxicol. 2016 Jul;62:18-26
pubmed: 27103539
Curr Med Chem. 2018 Feb 21;25(6):748-770
pubmed: 28990514
Chem Rev. 2015 Mar 25;115(6):2350-75
pubmed: 25804908
Mol Cell. 2007 Oct 12;28(1):91-106
pubmed: 17936707
Dose Response. 2015 Jul 29;13(3):1559325815598308
pubmed: 26674671
Curr Neuropharmacol. 2019;17(12):1109-1132
pubmed: 31362658
Chemosphere. 2001 Mar;42(8):917-22
pubmed: 11272914
Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):51-60
pubmed: 23257294
PLoS One. 2014 Dec 23;9(12):e115922
pubmed: 25535951
Epigenetics. 2020 Jun - Jul;15(6-7):664-683
pubmed: 31942817
J Pharm Biomed Anal. 2019 Feb 20;165:207-212
pubmed: 30553981
Food Chem Toxicol. 2019 Nov;133:110786
pubmed: 31470036
Reprod Toxicol. 2014 Aug;47:51-8
pubmed: 24933518
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cell Death Dis. 2015 May 07;6:e1747
pubmed: 25950477
Neurotoxicology. 2017 Dec;63:90-96
pubmed: 28939238
Mutat Res. 2015 Apr;774:33-9
pubmed: 25796969
Curr Environ Health Rep. 2014 Mar;1(1):90-100
pubmed: 25838989
Cell Physiol Biochem. 2017;43(5):1950-1960
pubmed: 29055943
Environ Health Perspect. 2014 Aug;122(8):775-86
pubmed: 24896072
Cell Signal. 2013 Oct;25(10):1939-48
pubmed: 23770291
Reproduction. 2016 Jan;151(1):R1-R13
pubmed: 26585413
Chemosphere. 2020 Sep;254:126819
pubmed: 32334263
Gene. 2014 Apr 10;539(1):117-24
pubmed: 24480449
Environ Res. 2018 Jul;164:45-52
pubmed: 29476947
Int J Biol Sci. 2017 Jul 6;13(7):852-867
pubmed: 28808418
Mol Biol Rep. 2019 Apr;46(2):2299-2305
pubmed: 30756332
Environ Int. 2015 Dec;85:352-79
pubmed: 26521216
Diabetologia. 2013 Sep;56(9):2059-67
pubmed: 23748860
Nat Rev Endocrinol. 2019 Jun;15(6):366-374
pubmed: 30842650
AJNR Am J Neuroradiol. 2020 Apr;41(4):566-572
pubmed: 32079598
JAMA. 2012 Sep 19;308(11):1113-21
pubmed: 22990270
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
Oncotarget. 2016 Sep 20;7(38):62312-62326
pubmed: 27694688