Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?
SNP (single nucleotide polymorphism)
chemotherapy
clinical implementation guidelines
drug label
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
17
08
2021
revised:
07
09
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients' clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy and minimizing toxicity. This is of great importance, especially in pediatric cancer and even more in complex malignancies such as neuroblastoma, where the rates of therapeutic success are still below those of many other types of tumors. The studies are mainly focused on germline genetic variants and in the present review, state of the art is presented: which are the variants that have a level of evidence high enough to be implemented in the clinic, and how to distinguish them from the ones that still need validation to confirm their utility. Further aspects as relevant characteristics regarding ontogeny and future directions in the research will also be discussed.
Identifiants
pubmed: 34575974
pii: ijms22189815
doi: 10.3390/ijms22189815
pmc: PMC8466270
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Int J Mol Sci. 2020 Apr 14;21(8):
pubmed: 32295184
J Clin Oncol. 2008 Mar 20;26(9):1504-10
pubmed: 18349403
Pharmacogenet Genomics. 2008 Jul;18(7):621-31
pubmed: 18551042
Lancet Oncol. 2008 Apr;9(4):392-9
pubmed: 18374293
Pharmacogenomics J. 2014 Jun;14(3):263-71
pubmed: 24165757
Cancer. 2012 Apr 1;118(7):1856-67
pubmed: 21887680
Clin Transl Oncol. 2021 Jan;23(1):183-189
pubmed: 32472454
Lung Cancer. 2011 Jan;71(1):82-8
pubmed: 20447721
Clin Pharmacol Ther. 2014 Nov;96(5):609-15
pubmed: 25054431
Lancet Oncol. 2018 Dec;19(12):1617-1629
pubmed: 30442501
J Popul Ther Clin Pharmacol. 2011;18:e134-51
pubmed: 21467604
Pharmacogenomics J. 2018 Apr;18(2):301-307
pubmed: 28485375
J Hum Genet. 2013 Jun;58(6):353-61
pubmed: 23677058
Pharmacogenomics J. 2018 Jan;18(1):64-69
pubmed: 27779248
Pharmacotherapy. 2014 Feb;34(2):140-50
pubmed: 24166985
J Clin Oncol. 2017 Aug 1;35(22):2580-2587
pubmed: 28471719
Pharmacogenet Genomics. 2011 Mar;21(3):152-61
pubmed: 20216335
J Biol Chem. 2001 Dec 7;276(49):46400-7
pubmed: 11581266
Drug Metab Lett. 2016;10(2):72-4
pubmed: 26908134
Expert Opin Investig Drugs. 2009 Jul;18(7):991-1000
pubmed: 19548853
Drug Metab Dispos. 2013 Oct;41(10):1725-31
pubmed: 23918665
Cancer Immunol Immunother. 2000 Feb;48(11):603-12
pubmed: 10663607
Cancer Prev Res (Phila). 2011 Feb;4(2):185-93
pubmed: 21292633
Br J Clin Pharmacol. 2016 Sep;82(3):683-95
pubmed: 27197003
Clin Cancer Res. 2019 Oct 15;25(20):6044-6051
pubmed: 31358541
Mol Pharmacol. 1994 Feb;45(2):352-8
pubmed: 8114683
Nat Genet. 2014 Aug;46(8):891-4
pubmed: 24974847
Pediatr Blood Cancer. 2018 Apr;65(4):
pubmed: 29286579
J Hum Genet. 2009 Oct;54(10):564-71
pubmed: 19696793
Crit Rev Oncol Hematol. 2018 Jun;126:154-167
pubmed: 29759558
J Pediatr. 2009 May;154(5):688-93
pubmed: 19159907
Asian Pac J Cancer Prev. 2012;13(5):2157-62
pubmed: 22901187
Br J Cancer. 2010 Mar 16;102(6):1003-9
pubmed: 20179710
Cytogenet Cell Genet. 1992;61(3):175-7
pubmed: 1424804
Br J Clin Pharmacol. 2016 Feb;81(2):327-40
pubmed: 26456622
Int J Cancer. 2008 Aug 1;123(3):577-85
pubmed: 18498133
Ann Oncol. 2015 Apr;26(4):624-644
pubmed: 25214541
Ther Drug Monit. 2016 Aug;38(4):423-31
pubmed: 26960170
Ther Clin Risk Manag. 2018 May 23;14:949-954
pubmed: 29872305
Eur J Cancer. 2014 Jan;50(2):388-96
pubmed: 24215845
Cancer Sci. 2008 Apr;99(4):816-23
pubmed: 18377430
Pharmacogenomics. 2013 Nov;14(14):1683-90
pubmed: 24192117
Clin Pharmacokinet. 2003;42(1):59-98
pubmed: 12489979
Pediatr Blood Cancer. 2018 Nov;65(11):e27363
pubmed: 30015396
Int J Mol Sci. 2016 Sep 08;17(9):
pubmed: 27618021
Fertil Steril. 2010 Jul;94(2):645-54
pubmed: 19376514
Circulation. 2005 Dec 13;112(24):3754-62
pubmed: 16330681
Pharmaceutics. 2011 Feb 07;3(1):53-72
pubmed: 24310425
Cancer Sci. 2008 Oct;99(10):2045-54
pubmed: 19016765
Clin Pharmacol Ther. 2012 Oct;92(4):414-7
pubmed: 22992668
Front Pediatr. 2015 Jul 29;3:68
pubmed: 26284229
Clin Exp Pharmacol Physiol. 2012 Sep;39(9):786-92
pubmed: 22725681
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9758-63
pubmed: 17537913
Leukemia. 2009 Mar;23(3):545-56
pubmed: 19005482
Pediatr Blood Cancer. 2011 Mar;56(3):361-7
pubmed: 21225912
Pharmacogenomics. 2014 Jun;15(8):1105-16
pubmed: 25084203
Lung Cancer. 2013 Jan;79(1):65-72
pubmed: 23127338
Expert Opin Drug Saf. 2018 Dec;17(12):1257-1262
pubmed: 30433831
Cancer Invest. 2005;23(1):19-25
pubmed: 15779864
Curr Opin Genet Dev. 2017 Feb;42:81-90
pubmed: 28458126
Drug Metab Dispos. 2016 Jul;44(7):1116-22
pubmed: 27052877
PLoS One. 2011;6(10):e26091
pubmed: 22016816