Molecular Proteomics and Signalling of Human Platelets in Health and Disease.
platelets
post-translational modification
proteins
receptors
signalling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Sep 2021
13 Sep 2021
Historique:
received:
20
07
2021
revised:
31
08
2021
accepted:
02
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis, besides other physiological and pathophysiological processes. These roles are tightly regulated by a complex network of signalling pathways. Mass spectrometry-based proteomic techniques are contributing not only to the identification and quantification of new platelet proteins, but also reveal post-translational modifications of these molecules, such as acetylation, glycosylation and phosphorylation. Moreover, target proteomic analysis of platelets can provide molecular biomarkers for genetic aberrations with established or non-established links to platelet dysfunctions. In this report, we review 67 reports regarding platelet proteomic analysis and signalling on a molecular base. Collectively, these provide detailed insight into the: (i) technical developments and limitations of the assessment of platelet (sub)proteomes; (ii) molecular protein changes upon ageing of platelets; (iii) complexity of platelet signalling pathways and functions in response to collagen, rhodocytin, thrombin, thromboxane A
Identifiants
pubmed: 34576024
pii: ijms22189860
doi: 10.3390/ijms22189860
pmc: PMC8468031
pii:
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Horizon 2020 Framework Programme
ID : TAPAS, TICARDIO
Organisme : Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen
ID : N/a
Organisme : Bundesministerium für Bildung und Forschung
ID : BMBF 01EO1503
Organisme : Deutsche Forschungsgemeinschaft
ID : ZA 639/4-1 and JU 2735/2-1
Organisme : Bundesministerium für Bildung und Forschung
ID : BMBF 01O1503
Organisme : Ministerio de Ciencia e Innovación
ID : PID2019-108727RB-100
Organisme : European Regional Development Fund
ID : ERDF
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