A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).
PLOD3
big data
enrichment analysis
immune infiltration
immunotherapy
pan-cancer
prognosis
tumor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
received:
29
07
2021
revised:
07
09
2021
accepted:
11
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
31
12
2021
Statut:
epublish
Résumé
The overexpression of the enzymes involved in the degradation of procollagen lysine is correlated with various tumor entities. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) expression was found to be correlated to the progression and migration of cancer cells in gastric, lung and prostate cancer. Here, we analyzed the gene expression, protein expression, and the clinical parameters of survival across 33 cancers based on the Clinical Proteomic Tumor Analysis Consortium (CPTAC), function annotation of the mammalian genome 5 (FANTOM5), Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), Human Protein Atlas (HPA) and The Cancer Genome Atlas (TCGA) databases. Genetic alteration, immune infiltration and relevant cellular pathways were analyzed in detail. PLOD3 expression negatively correlated with survival periods and the infiltration level of CD8
Identifiants
pubmed: 34576068
pii: ijms22189903
doi: 10.3390/ijms22189903
pmc: PMC8467482
pii:
doi:
Substances chimiques
PLOD3 protein, human
EC 1.14.11.-
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
EC 1.14.11.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Cancer. 2020 Jan 1;11(1):121-131
pubmed: 31892979
Front Oncol. 2020 Oct 29;10:517637
pubmed: 33194581
Annu Rev Biochem. 2005;74:739-89
pubmed: 15952902
Front Immunol. 2020 Aug 12;11:2039
pubmed: 32903444
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20
pubmed: 20576703
Int J Fertil Steril. 2020 Jul;14(2):102-109
pubmed: 32681621
Cancers (Basel). 2021 Feb 25;13(5):
pubmed: 33668819
Nature. 2019 May;569(7758):723-728
pubmed: 31043742
Ann Oncol. 2019 Jul 1;30(7):1096-1103
pubmed: 31038663
Cancer Discov. 2016 May;6(5):516-31
pubmed: 26811325
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
J Cell Biol. 1997 Jul 28;138(2):375-84
pubmed: 9230079
Am J Hum Genet. 2008 Oct;83(4):495-503
pubmed: 18834968
Sci Rep. 2020 Feb 24;10(1):3272
pubmed: 32094374
Nat Rev Drug Discov. 2019 Feb;18(2):99-115
pubmed: 30470818
Ann Oncol. 2017 Aug 1;28(8):1756-1766
pubmed: 28444111
FEBS Lett. 2008 Apr 9;582(8):1189-96
pubmed: 18325335
Clin Exp Metastasis. 2019 Apr;36(2):71-86
pubmed: 30847799
J Clin Oncol. 2015 Jun 10;33(17):1974-82
pubmed: 25605845
Prog Tumor Res. 2015;42:55-66
pubmed: 26382943
J Cell Physiol. 2019 Jun;234(6):8509-8521
pubmed: 30520029
Lancet Oncol. 2017 Dec;18(12):e731-e741
pubmed: 29208439
BMC Cancer. 2014 Jan 02;14:1
pubmed: 24383403
Biomed Res Int. 2020 Oct 19;2020:3418398
pubmed: 33134376
Nature. 2016 Jan 21;529(7586):326-35
pubmed: 26791723
Mol Cell. 2001 Nov;8(5):1041-52
pubmed: 11741539
Biomark Med. 2014;8(2):297-306
pubmed: 24521026
Cell Death Dis. 2019 Feb 15;10(3):156
pubmed: 30770789
Oncogene. 2006 Mar 9;25(10):1571-83
pubmed: 16247447
Matrix Biol. 2019 Aug;81:91-106
pubmed: 30463024
Oncotarget. 2018 Feb 28;9(21):15705-15720
pubmed: 29644003
J Hematol Oncol. 2019 Aug 28;12(1):86
pubmed: 31462327
Cell Mol Immunol. 2020 Aug;17(8):807-821
pubmed: 32612154
Nat Rev Cancer. 2020 Jun;20(6):301
pubmed: 32317743
Trends Mol Med. 2018 Jan;24(1):30-48
pubmed: 29246759
Gastroenterology. 2010 Jun;138(6):2073-2087.e3
pubmed: 20420947
Brief Funct Genomics. 2019 Mar 22;18(2):99-106
pubmed: 29554204
Support Care Cancer. 2019 Jun;27(6):1973-1984
pubmed: 30863893
Breast Care (Basel). 2018 Mar;13(1):16-21
pubmed: 29950962
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Front Cell Dev Biol. 2018 Jun 28;6:66
pubmed: 30003082
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612
pubmed: 33237311
Cancer Res. 2020 Aug 15;80(16):3222-3235
pubmed: 32605995
Clin Cancer Res. 2014 Feb 1;20(3):711-23
pubmed: 24218511
Genes Dev. 1999 May 15;13(10):1211-33
pubmed: 10346810
Matrix Biol. 2007 Jan;26(1):12-9
pubmed: 17056240
Mol Cell Probes. 2020 Oct;53:101608
pubmed: 32585183
J Bone Miner Res. 2019 Jul;34(7):1376-1382
pubmed: 30721533
Nat Genet. 2013 Oct;45(10):1134-40
pubmed: 24071852
Curr Opin Cell Biol. 2001 Jun;13(3):349-55
pubmed: 11343907
Cancer Res. 2017 Nov 15;77(22):6365-6374
pubmed: 28947422
J Immunother Cancer. 2019 Aug 5;7(1):204
pubmed: 31383016
Cell Death Dis. 2018 Nov 15;9(12):1138
pubmed: 30442941
Curr Top Microbiol Immunol. 2011;344:1-24
pubmed: 20512556
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Nat Commun. 2020 Mar 20;11(1):1494
pubmed: 32198421
Cell Tissue Res. 2016 Sep;365(3):495-506
pubmed: 27461257
Nat Rev Cancer. 2004 Jan;4(1):71-8
pubmed: 14708027
Cancers (Basel). 2019 Nov 21;11(12):
pubmed: 31766574
Genomics. 1994 Dec;24(3):464-71
pubmed: 7713497
J Med Genet. 2019 Sep;56(9):629-638
pubmed: 31129566
Am J Transl Res. 2020 Nov 15;12(11):7262-7274
pubmed: 33312365
Clin Lab. 2019 Jan 1;65(1):
pubmed: 30775879
Front Oncol. 2020 Sep 04;10:1695
pubmed: 33014843
Nat Genet. 2020 Nov;52(11):1139-1143
pubmed: 33106632
Cell Res. 2020 Jun;30(6):507-519
pubmed: 32467593
Front Genet. 2015 Aug 19;6:257
pubmed: 26347769
Int J Mol Sci. 2021 Jul 09;22(14):
pubmed: 34298996
Int J Biol Sci. 2017 Jul 18;13(8):1008-1018
pubmed: 28924382