Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis.
Animals
Aspirin
/ administration & dosage
Blood Platelets
/ drug effects
Brain
/ pathology
CD4-Positive T-Lymphocytes
/ drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Encephalomyelitis, Autoimmune, Experimental
/ drug therapy
Inflammation
/ immunology
Mice, Inbred C57BL
Multiple Sclerosis
/ blood
Platelet Aggregation Inhibitors
/ pharmacology
Thromboxane A2
/ biosynthesis
acetylsalicylic acid
experimental autoimmune encephalomyelitis
glycoprotein VI
multiple sclerosis
platelet factor 4
platelets
thromboxane
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
received:
10
08
2021
revised:
09
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Aside from the established immune-mediated etiology of multiple sclerosis (MS), compelling evidence implicates platelets as important players in disease pathogenesis. Specifically, numerous studies have highlighted that activated platelets promote the central nervous system (CNS)-directed adaptive immune response early in the disease course. Platelets, therefore, present a novel opportunity for modulating the neuroinflammatory process that characterizes MS. We hypothesized that the well-known antiplatelet agent acetylsalicylic acid (ASA) could inhibit neuroinflammation by affecting platelets if applied at low-dose and investigated its effect during experimental autoimmune encephalomyelitis (EAE) as a model to study MS. We found that oral administration of low-dose ASA alleviates symptoms of EAE accompanied by reduced inflammatory infiltrates and less extensive demyelination. Remarkably, the percentage of CNS-infiltrated CD4
Identifiants
pubmed: 34576080
pii: ijms22189915
doi: 10.3390/ijms22189915
pmc: PMC8465626
pii:
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Thromboxane A2
57576-52-0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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