Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
Animals
Cell Differentiation
Cell Line, Tumor
Cryotherapy
Down-Regulation
Female
Immunosuppression Therapy
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Neoplasms
/ immunology
Neutralization Tests
Phenotype
Radiofrequency Ablation
T-Lymphocytes, Regulatory
/ immunology
Tumor Necrosis Factor-alpha
/ blood
TNF-α
Treg fragility
cryo-thermal therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
17
08
2021
revised:
04
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Immunotherapy has emerged as a therapeutic pillar in tumor treatment, but only a minority of patients get benefit. Overcoming the limitations of immunosuppressive environment is effective for immunotherapy. Moreover, host T cell activation and longevity within tumor are required for the long-term efficacy. In our previous study, a novel cryo-thermal therapy was developed to improve long-term survival in B16F10 melanoma and s.q. 4T1 breast cancer mouse models. We determined that cryo-thermal therapy induced Th1-dominant CD4
Identifiants
pubmed: 34576115
pii: ijms22189951
doi: 10.3390/ijms22189951
pmc: PMC8468796
pii:
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Technology of the People's Republic of China
ID : 2016YFC0106201
Organisme : the Shanghai Science and Technology Commission of Shanghai Municipality
ID : 19DZ2280300
Références
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Sci Immunol. 2021 Mar 26;6(57):
pubmed: 33771887
Sci Rep. 2018 Aug 13;8(1):12079
pubmed: 30104686
J Immunol. 2013 Feb 1;190(3):1076-84
pubmed: 23277487
Cell Death Dis. 2019 Jan 10;10(1):27
pubmed: 30631042
Front Immunol. 2018 Mar 21;9:573
pubmed: 29619032
Cancer Immunol Res. 2014 Feb;2(2):91-8
pubmed: 24778273
Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3):
pubmed: 29661791
Cell Mol Immunol. 2021 Mar;18(3):523-527
pubmed: 32868910
Cell Death Dis. 2017 Mar 23;8(3):e2703
pubmed: 28333145
Cell. 2017 Jun 1;169(6):1130-1141.e11
pubmed: 28552348
J Immunol. 2001 Jun 1;166(11):6802-11
pubmed: 11359839
Front Immunol. 2012 Mar 21;3:51
pubmed: 22566933
Cancer Immunol Res. 2018 Aug;6(8):882-887
pubmed: 30068755
Front Immunol. 2018 Apr 19;9:784
pubmed: 29725328
J Immunother Cancer. 2020 Sep;8(2):
pubmed: 32938627
Immunity. 2007 Oct;27(4):635-46
pubmed: 17919943
Sci Rep. 2016 Jun 03;6:27136
pubmed: 27256519
Theranostics. 2016 Mar 21;6(6):773-94
pubmed: 27162549
Cell Res. 2017 Jan;27(1):109-118
pubmed: 27995907
J Exp Med. 2018 Jun 4;215(6):1507-1518
pubmed: 29789388
Front Immunol. 2018 Jan 22;9:14
pubmed: 29403496
Blood. 2011 Nov 17;118(20):5487-97
pubmed: 21972292
Immunology. 2000 May;100(1):63-9
pubmed: 10809960
Int Arch Allergy Immunol. 2001;125 Suppl 1:19-21
pubmed: 11408767
Cancer Sci. 2019 Jul;110(7):2080-2089
pubmed: 31102428
J Cell Physiol. 2019 Jun;234(6):8509-8521
pubmed: 30520029
Nat Rev Clin Oncol. 2019 Mar;16(3):151-167
pubmed: 30523282
Semin Cancer Biol. 2020 Oct;65:13-27
pubmed: 31362073
Cancer Res. 2009 Jul 15;69(14):5996-6004
pubmed: 19567680
Nat Rev Rheumatol. 2021 Aug;17(8):487-504
pubmed: 34226727
J Immunol. 2006 Sep 15;177(6):3669-76
pubmed: 16951326
Cancer Res. 2015 Sep 15;75(18):3747-59
pubmed: 26183926
J Allergy Clin Immunol Pract. 2021 Jun;9(6):2426-2439.e7
pubmed: 33545400
Front Immunol. 2017 Feb 23;8:194
pubmed: 28280496
Cancer Lett. 2017 Apr 28;392:17-25
pubmed: 28104443
Front Immunol. 2018 Mar 12;9:444
pubmed: 29593717
Cancers (Basel). 2021 Jan 08;13(2):
pubmed: 33430105
Cell Death Dis. 2019 Mar 4;10(3):216
pubmed: 30833570
Nat Commun. 2017 Dec 22;8(1):2256
pubmed: 29273790
Cell Mol Life Sci. 2018 Feb;75(4):689-713
pubmed: 29032503
J Immunother. 2018 Oct;41(8):369-378
pubmed: 29912725
Mol Cancer. 2019 Aug 23;18(1):128
pubmed: 31443694
Int J Hyperthermia. 2020;37(1):843-853
pubmed: 32654540
J Immunol. 2010 Apr 1;184(7):3570-81
pubmed: 20181891