Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation.
Apoptosis
/ drug effects
Cell Adhesion
/ drug effects
Cell Cycle
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Clone Cells
Curcumin
/ pharmacology
Human Umbilical Vein Endothelial Cells
/ metabolism
Humans
Integrins
/ metabolism
Light
Male
Neoplasm Metastasis
Prostatic Neoplasms
/ pathology
curcumin
growth
light irradiation
metastasis
proliferation
prostate cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
20
07
2021
revised:
25
08
2021
accepted:
13
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1-0.4 µg/mL) and subsequently irradiated with 1.65 J/cm
Identifiants
pubmed: 34576132
pii: ijms22189966
doi: 10.3390/ijms22189966
pmc: PMC8469895
pii:
doi:
Substances chimiques
Integrins
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany
ID : N/A
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