Kisspeptin Receptor on the Sperm Surface Reflects Epididymal Maturation in the Dog.
Canis familiaris
Kiss1
Kiss1R
Kisspeptin system
epididymis
sperm maturation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Sep 2021
19 Sep 2021
Historique:
received:
02
09
2021
revised:
14
09
2021
accepted:
16
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Alongside the well-known central modulatory role, the Kisspeptin system, comprising Kiss1, its cleavage products (Kisspeptins), and Kisspeptin receptor (Kiss1R), was found to regulate gonadal functions in vertebrates; however, its functional role in the male gamete and its localization during maturation have been poorly understood. The present study analyzed Kisspeptin system in dog testis and spermatozoa recovered from different segments of the epididymis, with focus on Kiss1R on sperm surface alongside the maturation during epididymal transit, demonstrated by modification in sperm kinetic, morphology, and protamination. The proteins Kiss1 and Kiss1R were detected in dog testis. The receptor Kiss1R only was detected in total protein extracts from epididymis spermatozoa, whereas dot blot revealed Kiss1 immunoreactivity in the epidydimal fluid. An increase of the Kiss1R protein on sperm surface along the length of the epididymis, with spermatozoa in the tail showing plasma membrane integrity and Kiss1R protein (
Identifiants
pubmed: 34576283
pii: ijms221810120
doi: 10.3390/ijms221810120
pmc: PMC8466692
pii:
doi:
Substances chimiques
Kisspeptins
0
Receptors, Kisspeptin-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Universities and Research
ID : Prin 2017 grant number 20175MT5EM to R.M. and R.P.
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