Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells.
HT-29
IL-8
calcilytic
calcimimetic
calcium-sensing receptor
colon cancer
enantiomer
inflammation
stereospecificity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Sep 2021
19 Sep 2021
Historique:
received:
10
08
2021
revised:
03
09
2021
accepted:
16
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Pharmacological allosteric agonists (calcimimetics) of the extracellular calcium-sensing receptor (CaSR) have substantial gastro-intestinal side effects and induce the expression of inflammatory markers in colon cancer cells. Here, we compared the effects of both CaSR-specific (
Identifiants
pubmed: 34576291
pii: ijms221810124
doi: 10.3390/ijms221810124
pmc: PMC8464956
pii:
doi:
Substances chimiques
Interleukin-8
0
Receptors, Calcium-Sensing
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund
ID : P 29948-B28
Organisme : Horizon 2020
ID : 675228
Organisme : Austrian Science Fund FWF
ID : P 29948
Pays : Austria
Organisme : Austrian Science Fund
ID : P 32840-B
Organisme : Herzfelder'sche Familienstiftung
ID : P 32840-B
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