Raman Spectroscopy as a Novel Method for the Characterization of Polydioxanone Medical Stents Biodegradation.
Raman spectrum
biodegradable polymer
crack growth
hydrolytic degradation
polydioxanone
stent
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
27
08
2021
revised:
17
09
2021
accepted:
17
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Polydioxanone (PPDX), as an FDA approved polymer in tissue engineering, is an important component of some promising medical devices, e.g., biodegradable stents. The hydrolytic degradation of polydioxanone stents plays a key role in the safety and efficacy of treatment. A new fast and convenient method to quantitatively evaluate the hydrolytic degradation of PPDX stent material was developed. PPDX esophageal stents were degraded in phosphate-buffered saline for 24 weeks. For the first time, the changes in Raman spectra during PPDX biodegradation have been investigated here. The level of PPDX hydrolytic degradation was determined from the Raman spectra by calculating the area under the 1732 cm
Identifiants
pubmed: 34576686
pii: ma14185462
doi: 10.3390/ma14185462
pmc: PMC8467320
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Univerzita Hradec Králové
ID : Specific research project 2107/2021
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