Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections.
SARs
antiviral agents
computer-aided drug design
human norovirus
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
received:
23
07
2021
revised:
11
08
2021
accepted:
17
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Human norovirus is the leading cause of acute gastroenteritis worldwide, affecting every year 685 million people. Norovirus outbreaks are associated with very significant economic losses, with an estimated societal cost of 60 billion USD per year. Despite this, no therapeutic options or vaccines are currently available to treat or prevent this infection. An antiviral therapy that can be used as treatment and as a prophylactic measure in the case of outbreaks is urgently needed. We previously described the computer-aided design and synthesis of novel small-molecule agents able to inhibit the replication of human norovirus in cell-based systems. These compounds are non-nucleoside inhibitors of the viral polymerase and are characterized by a terminal
Identifiants
pubmed: 34576691
pii: microorganisms9091795
doi: 10.3390/microorganisms9091795
pmc: PMC8468020
pii:
doi:
Types de publication
Journal Article
Langues
eng
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