Human Milk Oligosaccharide-Stimulated
Bifidobacterium
acetate
bronchitis
fucosylated glycans
machine learning based classification models
respiratory infections
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
12 Sep 2021
12 Sep 2021
Historique:
received:
16
08
2021
revised:
09
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
(1) Background: Human milk oligosaccharides (HMOs) may support immune protection, partly via their action on the early-life gut microbiota. Exploratory findings of a randomized placebo-controlled trial associated 2'fucosyllactose (2'FL) and lacto-N-neotetraose (LNnT) formula feeding with reduced risk for reported bronchitis and lower respiratory tract illnesses (LRTI), as well as changes in gut microbiota composition. We sought to identify putative gut microbial mechanisms linked with these clinical observations. (2) Methods: We used stool microbiota composition, metabolites including organic acids and gut health markers in several machine-learning-based classification tools related prospectively to experiencing reported bronchitis or LRTI, as compared to no reported respiratory illness. We performed preclinical epithelial barrier function modelling to add mechanistic insight to these clinical observations. (3) Results: Among the main features discriminant for infants who did not experience any reported bronchitis (
Identifiants
pubmed: 34576834
pii: microorganisms9091939
doi: 10.3390/microorganisms9091939
pmc: PMC8465161
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT01715246']
Types de publication
Journal Article
Langues
eng
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