Chagas Disease-Related Mortality in Spain, 1997 to 2018.
Chagas disease
HIV infection
Spain
aged
cardiopathy
female
male
mortality
neoplasm
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
20 Sep 2021
20 Sep 2021
Historique:
received:
11
08
2021
revised:
09
09
2021
accepted:
13
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Chagas disease (CD) is associated with excess mortality in infected people in endemic countries, but little information is available in non-endemic countries. The aim of the study was to analyze mortality in patients admitted to the hospital with CD in Spain. A retrospective, observational study using the Spanish National Hospital Discharge Database. We used the CD diagnostic codes of the 9th and 10th International Classification of Diseases to retrieve CD cases from the national public registry from 1997 to 2018. Of the 5022 hospital admissions in people with CD, there were 56 deaths (case fatality rate (CFR) 1.1%, 95% confidence interval (CI) 0.8%, 1.4%), 20 (35.7%) of which were considered directly related to CD. The median age was higher in those who died (54.5 vs. 38 years; The case fatality rate of CD hospitalization was about 1%. The mortality risk increased with age, male sex, cancer, and HIV infection.
Sections du résumé
BACKGROUND
BACKGROUND
Chagas disease (CD) is associated with excess mortality in infected people in endemic countries, but little information is available in non-endemic countries. The aim of the study was to analyze mortality in patients admitted to the hospital with CD in Spain.
METHODS
METHODS
A retrospective, observational study using the Spanish National Hospital Discharge Database. We used the CD diagnostic codes of the 9th and 10th International Classification of Diseases to retrieve CD cases from the national public registry from 1997 to 2018.
RESULTS
RESULTS
Of the 5022 hospital admissions in people with CD, there were 56 deaths (case fatality rate (CFR) 1.1%, 95% confidence interval (CI) 0.8%, 1.4%), 20 (35.7%) of which were considered directly related to CD. The median age was higher in those who died (54.5 vs. 38 years;
CONCLUSIONS
CONCLUSIONS
The case fatality rate of CD hospitalization was about 1%. The mortality risk increased with age, male sex, cancer, and HIV infection.
Identifiants
pubmed: 34576886
pii: microorganisms9091991
doi: 10.3390/microorganisms9091991
pmc: PMC8469044
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Institute of Health and Biomedical Research of Alicante
ID : 2020-0285)
Organisme : Institute of Health and Biomedical Research of Alicante
ID : 190295
Références
PLoS Negl Trop Dis. 2021 Mar 24;15(3):e0009281
pubmed: 33760816
Rev Soc Bras Med Trop. 2011 Nov-Dec;44(6):762-70
pubmed: 22231251
Rev Chilena Infectol. 2020 Aug;37(4):402-412
pubmed: 33399661
Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1991-7
pubmed: 22258424
Euro Surveill. 2020 Feb;25(8):
pubmed: 32127121
Am J Trop Med Hyg. 2011 Nov;85(5):820-5
pubmed: 22049034
Trop Med Infect Dis. 2021 Jan 27;6(1):
pubmed: 33513668
Acta Trop. 2009 Jul;111(1):51-5
pubmed: 19426663
Europace. 2019 Jul 1;21(7):1070-1078
pubmed: 30820579
Heart. 2018 Sep;104(18):1522-1528
pubmed: 29523589
Lancet. 2018 Jan 6;391(10115):82-94
pubmed: 28673423
PLoS Negl Trop Dis. 2015 Apr 17;9(4):e0003710
pubmed: 25884198
Eur Neurol. 2018;79(3-4):177-184
pubmed: 29539612
Stroke. 2005 May;36(5):965-70
pubmed: 15845889
Lancet Infect Dis. 2001 Sep;1(2):92-100
pubmed: 11871482
PLoS One. 2017 Dec 28;12(12):e0189449
pubmed: 29284005
Rev Panam Salud Publica. 2009 Oct;26(4):299-309
pubmed: 20107677
Glob Heart. 2015 Sep;10(3):173-80
pubmed: 26407513
Mediators Inflamm. 2014;2014:683230
pubmed: 25210230
Am J Cardiol. 2018 Feb 1;121(3):364-369
pubmed: 29191568
Circulation. 2013 Mar 12;127(10):1105-15
pubmed: 23393012
PLoS Negl Trop Dis. 2015 Feb 13;9(2):e0003540
pubmed: 25680190
Trans R Soc Trop Med Hyg. 2019 Jan 1;113(1):44-47
pubmed: 30295901
Parasit Vectors. 2016 Jan 27;9:42
pubmed: 26813568
Trop Med Int Health. 2020 Oct;25(10):1298-1305
pubmed: 32726864
Int J Cardiol. 1997 Jul 25;60(2):187-93
pubmed: 9226290
Infect Dis Poverty. 2021 Sep 15;10(1):117
pubmed: 34526137
PLoS Negl Trop Dis. 2014 Jul 24;8(7):e2865
pubmed: 25058013
Clin Microbiol Infect. 2011 Jul;17(7):1108-13
pubmed: 21073628
PLoS Negl Trop Dis. 2016 Jan 15;10(1):e0004379
pubmed: 26771528
J Trop Med. 2012;2012:534649
pubmed: 22969814
PLoS Negl Trop Dis. 2018 Sep 28;12(9):e0006798
pubmed: 30265661
Arch Gynecol Obstet. 2012 Apr;285(4):919-23
pubmed: 21927962
Infect Dis Poverty. 2021 Apr 23;10(1):55
pubmed: 33892808
Parasitology. 2020 Nov;147(13):1552-1558
pubmed: 32741387
Stroke. 2005 Sep;36(9):2015-7
pubmed: 16081855
Rev Soc Bras Med Trop. 2021 Feb 26;54:e07682020
pubmed: 33656153
PLoS Negl Trop Dis. 2017 May 18;11(5):e0005542
pubmed: 28545053