The Effect of Betulin Diphosphate in Wound Dressings of Bacterial Cellulose-ZnO NPs on Platelet Aggregation and the Activity of Oxidoreductases Regulated by NAD(P)+/NAD(P)H-Balance in Burns on Rats.
Acetobacteraceae
/ chemistry
Animals
Bandages
Burns
/ physiopathology
Cellulose
/ chemistry
Diphosphates
/ chemistry
Glucosephosphate Dehydrogenase
/ metabolism
Glutathione Reductase
/ metabolism
Humans
Laser-Doppler Flowmetry
Male
Metal Nanoparticles
/ chemistry
NADP
/ metabolism
Platelet Aggregation
/ drug effects
Rats, Wistar
Spectroscopy, Fourier Transform Infrared
Triterpenes
/ chemistry
Wound Healing
/ drug effects
ZnO NPs
anti-aggregation
bacterial cellulose
betulin diphosphate
oxidoreductase activity
wound dressings
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
06
08
2021
revised:
04
09
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The inhibition of platelet aggregation, and the activity of oxidoreductases and microhemocirculation in a burn wound on the treatment of burns with wound dressings based on bacterial nanocellulose (BC)-zinc oxide nanoparticles (ZnO NPs)-betulin diphosphate (BDP) were studied. The control of the treatment by BC-ZnO NPs-BDP on burned rats by the noninvasive DLF method showed an increase in perfusion and the respiratory component in wavelet spectra, characterizing an improvement in oxygen saturation in the wound. The study on the volunteers' blood found the inhibition of ADP-induced platelet aggregation by 30-90%. Disaggregation depends on the dose under the action of the ionized form of BDP and ZnO NPs-BDP in a phosphate buffer; it was reversible and had two waves. It was shown on rats that the specific activity of LDH
Identifiants
pubmed: 34576949
pii: molecules26185478
doi: 10.3390/molecules26185478
pmc: PMC8469126
pii:
doi:
Substances chimiques
Diphosphates
0
Triterpenes
0
NADP
53-59-8
betulin
6W70HN7X7O
Cellulose
9004-34-6
Glucosephosphate Dehydrogenase
EC 1.1.1.49
Glutathione Reductase
EC 1.8.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : FZRS-2020-0003
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