Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy.
Animals
Biomimetics
Catalase
/ chemistry
Cell Line
Cell Survival
/ drug effects
Glucose Oxidase
/ chemistry
Humans
Hydrogen Peroxide
/ metabolism
Infrared Rays
Mice
Nanoparticles
/ chemistry
Neoplasms
/ therapy
Photochemotherapy
/ methods
Polymers
/ chemical synthesis
Porphyrins
/ chemical synthesis
Singlet Oxygen
/ metabolism
nanoreactor
photodynamic therapy
polymer nanocapsule
starvation therapy
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 Sep 2021
16 Sep 2021
Historique:
received:
28
08
2021
revised:
13
09
2021
accepted:
14
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
20
11
2021
Statut:
epublish
Résumé
The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H
Identifiants
pubmed: 34577080
pii: molecules26185609
doi: 10.3390/molecules26185609
pmc: PMC8470963
pii:
doi:
Substances chimiques
Polymers
0
Porphyrins
0
Singlet Oxygen
17778-80-2
Hydrogen Peroxide
BBX060AN9V
Glucose Oxidase
EC 1.1.3.4
Catalase
EC 1.11.1.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key R&D Program of China
ID : Grant No. 2020YFA0908500 and No. 2018YFA0901600
Organisme : National Natural Science Foundation of China
ID : No. 22001054, 22075065
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