Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives.
cancer metastasis
drug design and development
hypersialylation
sialyltransferase
sialyltransferase inhibitors
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Sep 2021
18 Sep 2021
Historique:
received:
30
08
2021
revised:
15
09
2021
accepted:
15
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
12
11
2021
Statut:
epublish
Résumé
Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, which then blocks the sialic acid recognition pathway and leads to deterioration of cell motility and invasion. A vast amount of evidence for the in vitro and in vivo effects of sialyltransferase inhibition or knockdown on tumor progression and tumor cell metastasis or colonization has been accumulated over the past decades. In this regard, this review comprehensively discusses the results of studies that have led to the recent discovery and development of sialyltransferase inhibitors, their potential biomedical applications in the treatment of cancer metastasis, and their current limitations and future opportunities.
Identifiants
pubmed: 34577144
pii: molecules26185673
doi: 10.3390/molecules26185673
pmc: PMC8470674
pii:
doi:
Substances chimiques
Sialyltransferases
EC 2.4.99.-
N-acetyllactosaminide alpha-2,3-sialyltransferase
EC 2.4.99.6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Academia Sinica
ID : AS-KPQ-110-EIMD
Organisme : Academia Sinica
ID : AS-KPQ-109-BioMed
Organisme : Academia Sinica
ID : AS-KPQ-110-BioMed
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 109-0210-01-18-02
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 110-0210-01-22-02
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 109-2113-M-001-014
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 110-2113-M-001-037
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