Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in

Animals Antimalarials / chemistry DNA / chemistry Dihydroorotate Dehydrogenase Drug Discovery Drug Resistance Enzyme Inhibitors / chemistry Epigenesis, Genetic Histone Deacetylases / metabolism Humans Malaria, Falciparum / drug therapy Methyltransferases / antagonists & inhibitors Mitochondria / metabolism Oxidoreductases Acting on CH-CH Group Donors / antagonists & inhibitors Plasmodium falciparum / drug effects Quinazolines / chemistry Signal Transduction Structure-Activity Relationship
activities drug candidates epigenetic malaria mitochondria synthesis

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
21 Sep 2021
Historique:
received: 07 08 2021
revised: 14 09 2021
accepted: 16 09 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 17 11 2021
Statut: epublish

Résumé

Despite many efforts, malaria remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by

Identifiants

DOI: 10.3390/molecules26185711 PMID: 34577183 PMC: PMC8467436
pubmed: 34577183
pii: molecules26185711
doi: 10.3390/molecules26185711
pmc: PMC8467436
pii:
doi:

Substances chimiques

Antimalarials 0
Dihydroorotate Dehydrogenase 0
Enzyme Inhibitors 0
Quinazolines 0
DNA 9007-49-2
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-
Methyltransferases EC 2.1.1.-
Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Christina L Koumpoura (CL)

CNRS, LCC (Laboratoire de Chimie de Coordination), Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, France.
ORCID: 0000-0001-6819-7266

Anne Robert (A)

CNRS, LCC (Laboratoire de Chimie de Coordination), Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, France.
ORCID: 0000-0002-9092-6776

Constantinos M Athanassopoulos (CM)

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece.
ORCID: 0000-0002-7549-1911

Michel Baltas (M)

CNRS, LCC (Laboratoire de Chimie de Coordination), Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydroorotate dehydrogenase › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Antimalarial Inhibitors Targeting Epigenetics...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Antimalarial Inhibitors Targeting Epigenetics...