Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies.
biologically active compounds
dermal drug delivery
liposomes
nanoemulsions
nanostructured lipid carriers
phytophenols
polyphenols
skin permeation
solid lipid nanoparticles
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
received:
30
07
2021
revised:
17
08
2021
accepted:
20
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances. From the perspective of dermatology, the most important benefits for human health are their pharmacological effects on oxidation processes, inflammation, vascular pathology, immune response, precancerous and oncological lesions or formations, and microbial growth. Because the nature of phenolic compounds is designed to fit the phytochemical needs of plants and not the biopharmaceutical requirements for a specific route of delivery (dermal or other), their utilization in cutaneous formulations sets challenges to drug development. These are encountered often due to insufficient water solubility, high molecular weight and low permeation and/or high reactivity (inherent for the set of representatives) and subsequent chemical/photochemical instability and ionizability. The inclusion of phenolic phytochemicals in lipid-based nanocarriers (such as nanoemulsions, liposomes and solid lipid nanoparticles) is so far recognized as a strategic physico-chemical approach to improve their in situ stability and introduction to the skin barriers, with a view to enhance bioavailability and therapeutic potency. This current review is focused on recent advances and achievements in this area.
Identifiants
pubmed: 34577536
pii: ph14090837
doi: 10.3390/ph14090837
pmc: PMC8471500
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Medical University - Varna
ID : Fund "Nauka" Project № 18027
Références
Nutrients. 2017 Nov 30;9(12):
pubmed: 29189718
Biomedicines. 2021 Jun 30;9(7):
pubmed: 34209369
Artif Cells Nanomed Biotechnol. 2016;44(1):27-40
pubmed: 24813223
J Agric Food Chem. 2005 Jun 1;53(11):4355-60
pubmed: 15913295
Int J Cosmet Sci. 2015 Oct;37(5):455-64
pubmed: 25712493
Colloids Surf B Biointerfaces. 2015 Dec 1;136:1004-10
pubmed: 26579567
Antimicrob Agents Chemother. 1997 May;41(5):992-8
pubmed: 9145858
Biochim Biophys Acta. 2013 Nov;1828(11):2751-6
pubmed: 23938956
Evid Based Complement Alternat Med. 2014;2014:793629
pubmed: 25254058
Eur J Pharm Sci. 2012 Dec 18;47(5):857-64
pubmed: 22609526
Oxid Med Cell Longev. 2016;2016:7432797
pubmed: 27738491
Dermatol Clin. 2017 Apr;35(2):257-265
pubmed: 28317534
J Clin Med. 2019 Dec 31;9(1):
pubmed: 31906141
Neurotox Res. 2006 Jan;9(1):29-37
pubmed: 16464750
Eur J Pharmacol. 2011 Jan 25;651(1-3):18-25
pubmed: 21074525
3 Biotech. 2015 Apr;5(2):123-127
pubmed: 28324579
PLoS One. 2015 Mar 17;10(3):e0119564
pubmed: 25781975
Arch Dermatol Res. 2014 Jul;306(5):475-87
pubmed: 24414332
Int J Cosmet Sci. 2002 Dec;24(6):357-66
pubmed: 18494890
Front Pharmacol. 2015 Sep 30;6:219
pubmed: 26483690
Phytother Res. 2011 May;25(5):686-93
pubmed: 21077257
Int J Pharm. 2003 Jun 4;258(1-2):141-51
pubmed: 12753761
Pharmaceuticals (Basel). 2021 Jul 23;14(8):
pubmed: 34451808
PLoS One. 2015 Jul 09;10(7):e0131026
pubmed: 26158639
Eur Surg Res. 2012;49(1):35-43
pubmed: 22797712
Mol Med Rep. 2015 Jun;11(6):4285-90
pubmed: 25625855
JAMA Dermatol. 2017 May 1;153(5):406-412
pubmed: 28249066
Pharm Sci Technol Today. 2000 Sep 1;3(9):318-326
pubmed: 10996573
Ultrason Sonochem. 2017 Jul;37:478-489
pubmed: 28427660
Biomolecules. 2020 Aug 16;10(8):
pubmed: 32824310
Food Chem Toxicol. 2019 Mar;125:383-391
pubmed: 30684603
Food Res Int. 2017 Oct;100(Pt 1):731-739
pubmed: 28873743
Heliyon. 2020 Dec 01;6(12):e05461
pubmed: 33305043
BMC Complement Altern Med. 2009 Aug 04;9:27
pubmed: 19653897
Biotechnol Rep (Amst). 2019 Aug 20;24:e00370
pubmed: 31516850
Int J Mol Sci. 2020 Jan 21;21(3):
pubmed: 31973112
J Palliat Med. 2012 Feb;15(2):146-8
pubmed: 22313461
Mol Biol Rep. 2015 Jan;42(1):267-75
pubmed: 25262359
ISRN Pharmacol. 2014 Mar 26;2014:952943
pubmed: 25006494
J Agric Food Chem. 2010 Jun 23;58(12):7423-31
pubmed: 20550219
Am J Clin Dermatol. 2016 Aug;17(4):369-85
pubmed: 27164914
Pharm Dev Technol. 2012 Mar-Apr;17(2):177-86
pubmed: 21047275
Molecules. 2021 Jun 05;26(11):
pubmed: 34198892
Microbiol Res. 2017 Mar;196:44-68
pubmed: 28164790
Planta Med. 2014 Feb;80(2-3):109-20
pubmed: 24214835
Int J Pharm. 2021 Jan 25;593:120125
pubmed: 33253799
AMB Express. 2020 Oct 19;10(1):187
pubmed: 33078274
Curr Pharm Des. 2015;21(20):2823-9
pubmed: 25925115
Front Immunol. 2018 Apr 16;9:639
pubmed: 29713318
Medicines (Basel). 2018 Aug 25;5(3):
pubmed: 30149600
Integr Med (Encinitas). 2016 Mar;15(1):33-6
pubmed: 27053934
Antimicrob Resist Infect Control. 2019 Jul 16;8:118
pubmed: 31346459
Iran J Pharm Res. 2018 Winter;17(1):225-235
pubmed: 29755554
J Agric Food Chem. 2010 Feb 10;58(3):1685-90
pubmed: 20055412
Arch Dermatol Res. 2011 Nov;303(9):607-21
pubmed: 21805180
Sci Rep. 2020 Feb 13;10(1):2611
pubmed: 32054964
J Nutr Biochem. 2002 Oct;13(10):572-584
pubmed: 12550068
J Dermatol Sci. 2009 Sep;55(3):179-84
pubmed: 19574027
Toxicol Res. 2015 Jun;31(2):97-104
pubmed: 26191378
Eur J Pharm Sci. 2018 Jan 15;112:159-167
pubmed: 29183800
Cold Spring Harb Perspect Med. 2014 Dec 01;4(12):a015339
pubmed: 25452424
Pharm Res. 2009 May;26(5):1217-25
pubmed: 18810327
Molecules. 2020 Mar 23;25(6):
pubmed: 32210106
Photomed Laser Surg. 2010 Oct;28(5):679-84
pubmed: 20961233
ScientificWorldJournal. 2013 Dec 29;2013:162750
pubmed: 24470791
Free Radic Biol Med. 2014 Oct;75:149-55
pubmed: 25041725
J Pharm Biomed Anal. 2006 Jan 23;40(1):206-10
pubmed: 16111850
J Ethnopharmacol. 2015 Apr 22;164:16-21
pubmed: 25666430
Pigment Cell Melanoma Res. 2019 Jul;32(4):540-552
pubmed: 30767390
Int J Mol Sci. 2019 Feb 23;20(4):
pubmed: 30813425
Curr Pharm Des. 2020;26(27):3203-3217
pubmed: 32452322
Analyst. 2003 May;128(5):427-33
pubmed: 12790192
Antimicrob Agents Chemother. 2004 Jun;48(6):1968-73
pubmed: 15155186
Med Hypotheses. 2018 Dec;121:26-30
pubmed: 30396481
Sci Rep. 2020 Mar 27;10(1):5564
pubmed: 32221407
Planta Med. 2017 Mar;83(5):398-404
pubmed: 27124246
Eur J Cancer. 2006 Dec;42(18):3260-6
pubmed: 17045795
J Ethnopharmacol. 2008 Sep 2;119(1):53-7
pubmed: 18588964
Molecules. 2016 May 11;21(5):
pubmed: 27187321
Antimicrob Agents Chemother. 2002 Jul;46(7):2266-8
pubmed: 12069986
Nutrients. 2020 Aug 21;12(9):
pubmed: 32825564
Nutrients. 2019 Dec 28;12(1):
pubmed: 31905647
Oxid Med Cell Longev. 2019 Aug 5;2019:6175804
pubmed: 31467634
Molecules. 2021 Jun 11;26(12):
pubmed: 34208257
J Dermatol Sci. 2014 Nov;76(2):81-9
pubmed: 25242498
Bioorg Med Chem. 2004 Jul 1;12(13):3521-7
pubmed: 15186836
Fitoterapia. 2015 Mar;101:179-87
pubmed: 25598188
J Control Release. 2018 Jan 28;270:203-225
pubmed: 29199062
Front Microbiol. 2017 Jun 13;8:1103
pubmed: 28659908
Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):517-9
pubmed: 16127829
J Am Acad Dermatol. 2005 Jul;53(1 Suppl 1):S3-16
pubmed: 15968262
AAPS PharmSciTech. 2016 Dec;17(6):1468-1476
pubmed: 26842800
Sci Rep. 2020 Sep 11;10(1):14951
pubmed: 32917912
Br J Dermatol. 2021 Feb;184(2):189-190
pubmed: 33544440
Microb Drug Resist. 2013 Aug;19(4):256-65
pubmed: 23480526
Molecules. 2019 Nov 27;24(23):
pubmed: 31783535
Pharmaceuticals (Basel). 2019 Jun 21;12(2):
pubmed: 31234364
Int J Nanomedicine. 2014 Apr 10;9:1823-32
pubmed: 24748792
Life Sci. 2015 Nov 15;141:202-11
pubmed: 26437269
Drug Dev Ind Pharm. 2018 Oct;44(10):1701-1712
pubmed: 29938544
Carbohydr Res. 2019 Jan 15;472:42-49
pubmed: 30471509
J Invest Dermatol. 2007 Jan;127(1):222-32
pubmed: 16902416
Chem Res Toxicol. 2009 Dec;22(12):2017-28
pubmed: 19928967
Pharmaceutics. 2017 Sep 21;9(4):
pubmed: 28934172
Antioxidants (Basel). 2019 Jul 25;8(8):
pubmed: 31349656
J Biol Chem. 2004 Dec 3;279(49):51163-71
pubmed: 15383533
Adv Drug Deliv Rev. 2002 Nov 1;54 Suppl 1:S131-55
pubmed: 12460720
Curr Med Chem. 2015;22(1):132-49
pubmed: 25245513
Carcinogenesis. 2001 Feb;22(2):287-94
pubmed: 11181450
Fitoterapia. 2016 Jan;108:13-9
pubmed: 26592852
Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):121-9
pubmed: 16487045
Biosci Biotechnol Biochem. 2017 Feb;81(2):226-230
pubmed: 27756183
Mar Drugs. 2013 Jun 03;11(6):1899-908
pubmed: 23736765
J Fluoresc. 2013 Jul;23(4):829-37
pubmed: 23525972
Phytomedicine. 2006 Feb;13(3):187-91
pubmed: 16428027
Pharmazie. 2003 Mar;58(3):200-3
pubmed: 12685814
Pharmaceutics. 2021 May 05;13(5):
pubmed: 34062983
Microorganisms. 2021 Jan 31;9(2):
pubmed: 33572685
Antioxidants (Basel). 2019 Aug 05;8(8):
pubmed: 31387266
Antioxidants (Basel). 2020 May 15;9(5):
pubmed: 32429080
Antimicrob Agents Chemother. 2001 Jun;45(6):1737-42
pubmed: 11353619
Molecules. 2014 Aug 25;19(9):12940-8
pubmed: 25157464
Antioxid Redox Signal. 2013 May 10;18(14):1818-92
pubmed: 22794138
Biomed Res Int. 2014;2014:814590
pubmed: 24804249
Molecules. 2014 Dec 01;19(12):20091-112
pubmed: 25470276
Arch Pharm Res. 2005 Nov;28(11):1251-6
pubmed: 16350851
Mol Plant Pathol. 2010 Sep;11(5):705-19
pubmed: 20696007
AAPS PharmSciTech. 2018 Nov;19(8):3490-3500
pubmed: 30218265
Compr Rev Food Sci Food Saf. 2017 Nov;16(6):1243-1268
pubmed: 33371586
Toxicol Res (Camb). 2018 Aug 27;7(6):1012-1019
pubmed: 30542599
Int J Nanomedicine. 2014 Aug 11;9:3855-64
pubmed: 25143733
Molecules. 2012 Jul 26;17(8):8898-907
pubmed: 22836209
Drug Dev Ind Pharm. 2015;41(9):1464-9
pubmed: 25224342
Biol Pharm Bull. 2009 Mar;32(3):489-92
pubmed: 19252301
Vet World. 2018 May;11(5):627-635
pubmed: 29915501
Drug Des Devel Ther. 2017 Jan 11;11:163-173
pubmed: 28138219
PLoS One. 2014 Sep 19;9(9):e107435
pubmed: 25238543
Virology. 2008 Apr 10;373(2):239-47
pubmed: 18191976
Int J Mol Sci. 2013 Jan 16;14(1):1802-21
pubmed: 23325048
Int J Mol Sci. 2016 Feb 18;17(2):160
pubmed: 26901191
J Pharm Pharmacol. 1999 Feb;51(2):193-200
pubmed: 10217319
Am J Dermatopathol. 2009 Feb;31(1):53-60
pubmed: 19155726
Pharmaceutics. 2018 Oct 18;10(4):
pubmed: 30340327
Biochem Pharmacol. 2002 Jan 15;63(2):99-104
pubmed: 11841782
Pharm Dev Technol. 2019 Feb;24(2):222-234
pubmed: 29565215
Anal Bioanal Chem. 2012 Jan;402(2):975-82
pubmed: 22057718
J Inorg Biochem. 1992 Jun;46(4):251-7
pubmed: 1402876
Melanoma Res. 2011 Apr;21(2):115-26
pubmed: 21317816
Antioxidants (Basel). 2020 Aug 08;9(8):
pubmed: 32784453
Pharmacol Rep. 2019 Feb;71(1):156-166
pubmed: 30550996
J Agric Food Chem. 2008 Sep 10;56(17):7600-5
pubmed: 18700778
Open Access Maced J Med Sci. 2018 Jan 21;6(1):203-207
pubmed: 29484024
Indian J Dermatol. 2012 Sep;57(5):394-5
pubmed: 23112363
Int J Mol Sci. 2016 Sep 15;17(9):
pubmed: 27649161
J Ethnopharmacol. 2010 Oct 5;131(3):511-21
pubmed: 20659547
Biomed Res Int. 2019 Oct 16;2019:7010467
pubmed: 31737673
Front Pharmacol. 2020 Dec 03;11:594202
pubmed: 33424605
Evid Based Complement Alternat Med. 2019 Apr 2;2019:2676307
pubmed: 31061668
Hautarzt. 2002 May;53(5):316-21
pubmed: 12063742
Int J Pharm. 2019 Jun 10;564:299-307
pubmed: 31015007
Basic Life Sci. 1999;66:483-94
pubmed: 10800458
Burns. 2001 Jun;27(4):319-27
pubmed: 11348739
Am J Cardiol. 2003 Feb 6;91(3A):7A-11A
pubmed: 12645638
Eur J Pharm Biopharm. 2018 May;126:115-122
pubmed: 28870756
Clin Dermatol. 2008 Jul-Aug;26(4):347-57
pubmed: 18691514
Oncotarget. 2017 Jun 13;8(24):38214-38226
pubmed: 28465469
Free Radic Biol Med. 2015 Aug;85:1-11
pubmed: 25845487
Interdiscip Toxicol. 2011 Dec;4(4):173-83
pubmed: 22319251
J Agric Food Chem. 2009 Aug 26;57(16):7596-604
pubmed: 20349925
Molecules. 2014 Dec 12;19(12):20780-807
pubmed: 25514222
Cancer Prev Res (Phila). 2014 Oct;7(10):1056-66
pubmed: 25104643
J Agric Food Chem. 2011 May 11;59(9):4527-36
pubmed: 21425781
Int J Pharm. 2010 Jul 15;394(1-2):60-7
pubmed: 20438820
Biochim Biophys Acta. 2014 Oct;1838(10):2670-7
pubmed: 25016053
Nutrients. 2018 Nov 02;10(11):
pubmed: 30400131
Int J Gynecol Cancer. 2012 Mar;22(3):360-6
pubmed: 22228428
Biomed Res Int. 2013;2013:607109
pubmed: 23509751
Stem Cells Int. 2019 Dec 31;2019:6789823
pubmed: 32082386
J Photochem Photobiol B. 2013 Aug 5;125:146-54
pubmed: 23816959
Mol Nutr Food Res. 2011 Nov;55(11):1677-89
pubmed: 22045655
Fitoterapia. 2016 Dec;115:74-85
pubmed: 27693342
PLoS One. 2016 Oct 27;11(10):e0165575
pubmed: 27788249
Nanoscale Res Lett. 2013 Feb 22;8(1):102
pubmed: 23432972
J Cosmet Sci. 2001 Sep-Oct;52(5):313-24
pubmed: 11567210
Open Access Maced J Med Sci. 2018 Jan 21;6(1):170-175
pubmed: 29484020
Pharmacogn Rev. 2014 Jan;8(15):52-60
pubmed: 24600196
Arch Dermatol Res. 2014 Sep;306(7):601-17
pubmed: 24895176
Antioxidants (Basel). 2020 Oct 15;9(10):
pubmed: 33076501
J Agric Food Chem. 2012 Dec 26;60(51):12531-9
pubmed: 23205662
Arch Pharm Res. 2006 Dec;29(12):1187-92
pubmed: 17225471
Nanomedicine (Lond). 2014;9(8):1223-38
pubmed: 23987096
J Agric Food Chem. 2013 Dec 26;61(51):12598-603
pubmed: 24328319
Molecules. 2019 May 29;24(11):
pubmed: 31146392
BMC Complement Altern Med. 2014 Oct 07;14:381
pubmed: 25292439
Biochem Biophys Res Commun. 2013 Jun 7;435(3):361-6
pubmed: 23669037
J Food Sci. 2016 Feb;81(2):N494-501
pubmed: 26766628
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67
pubmed: 23991888
Int J Nanomedicine. 2013;8:13-22
pubmed: 23293516
Res Pharm Sci. 2018 Aug;13(4):288-303
pubmed: 30065762
Molecules. 2020 Jun 13;25(12):
pubmed: 32545813
Pharmaceutics. 2011 Nov 04;3(4):793-829
pubmed: 24309309
Phytother Res. 2006 Nov;20(11):921-34
pubmed: 16841367
Antioxidants (Basel). 2019 Sep 06;8(9):
pubmed: 31500121
Int J Environ Res Public Health. 2018 Oct 22;15(10):
pubmed: 30360435
J Cosmet Dermatol. 2020 Dec;19(12):3258-3261
pubmed: 33098161
Biol Pharm Bull. 2018;41(1):73-79
pubmed: 29311485
Int J Antimicrob Agents. 2005 Nov;26(5):343-56
pubmed: 16323269
Evid Based Complement Alternat Med. 2020 Apr 14;2020:2416837
pubmed: 32382280
Drug Deliv Transl Res. 2017 Apr;7(2):325-332
pubmed: 28188607
Oxid Med Cell Longev. 2020 Sep 9;2020:5307614
pubmed: 32963698
Bioorg Med Chem. 2008 Apr 1;16(7):4009-18
pubmed: 18249545
J Food Drug Anal. 2015 Sep;23(3):545-551
pubmed: 28911714
J Ethnopharmacol. 2007 Sep 25;113(3):517-20
pubmed: 17719731
Antioxidants (Basel). 2020 Dec 12;9(12):
pubmed: 33322700
Curr Opin Immunol. 2013 Dec;25(6):676-82
pubmed: 24238922
Chin Med. 2018 Oct 19;13:51
pubmed: 30364385
Drug Des Devel Ther. 2015 Jul 13;9:3507-18
pubmed: 26203223
Electrophoresis. 2005 May;26(10):1886-95
pubmed: 15832299
Molecules. 2018 Feb 23;23(2):
pubmed: 29473847
Oncol Lett. 2019 May;17(5):4068-4084
pubmed: 30944600
Bioorg Med Chem Lett. 2005 May 16;15(10):2633-5
pubmed: 15863332
Pharm Biol. 2016 Sep;54(9):1865-72
pubmed: 26912420
Int J Nanomedicine. 2012;7:1841-50
pubmed: 22605933
Int J Pharm. 2020 May 30;582:119336
pubmed: 32304728
Molecules. 2021 Jan 10;26(2):
pubmed: 33435259
PLoS One. 2012;7(9):e44524
pubmed: 22957077
Int J Nanomedicine. 2015 Feb 02;10:975-99
pubmed: 25678787
Biochem Pharmacol. 2005 May 15;69(10):1421-32
pubmed: 15857606
An Bras Dermatol. 2018 Jan-Feb;93(1):104-107
pubmed: 29641707
Int J Pharm. 2017 Jun 30;526(1-2):506-515
pubmed: 28502895