Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues.
HDAC inhibitors
Vorinostat
dibenzodiazocines
histone deacetylase
hydroxamic acid
selectivity
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
26 Aug 2021
26 Aug 2021
Historique:
received:
28
07
2021
revised:
19
08
2021
accepted:
23
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl group with various tricyclic 'caps' possessing a central, eight-membered, heterocyclic ring, and investigated the HDAC activity and cytotoxic effect on the cancer and normal cell lines. We found that 3 out of the 19 compounds, based on dibenzo[
Identifiants
pubmed: 34577551
pii: ph14090851
doi: 10.3390/ph14090851
pmc: PMC8470702
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : Diamentowy Grant V 0072/DIA/2016/45
Organisme : Narodowe Centrum Badań i Rozwoju
ID : LIDER/37/0137/L-9/17/NCBR/2018
Références
Anticancer Res. 2017 Jan;37(1):35-46
pubmed: 28011471
Eur J Med Chem. 2013 Aug;66:56-68
pubmed: 23792316
Int J Mol Sci. 2019 Jun 18;20(12):
pubmed: 31216674
Ther Adv Chronic Dis. 2019 Jul 18;10:2040622319862697
pubmed: 31367296
Nutrients. 2018 Aug 18;10(8):
pubmed: 30126190
Curr Top Med Chem. 2019;19(12):1005-1040
pubmed: 30827245
Cancers (Basel). 2019 Nov 01;11(11):
pubmed: 31683883
Front Cell Dev Biol. 2020 Sep 03;8:576391
pubmed: 33015069
Int J Mol Sci. 2018 Jan 05;19(1):
pubmed: 29304031
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6
pubmed: 12576549
Trends Pharmacol Sci. 2017 Apr;38(4):363-377
pubmed: 28139258
Molecules. 2019 Feb 19;24(4):
pubmed: 30791388
Cancers (Basel). 2018 Dec 27;11(1):
pubmed: 30591655
Molecules. 2020 Jun 20;25(12):
pubmed: 32575784
Metabolites. 2014 Sep 12;4(3):807-30
pubmed: 25222834
Int J Mol Sci. 2020 Feb 21;21(4):
pubmed: 32098220
Med Res Rev. 2018 Sep;38(6):2058-2109
pubmed: 29733427
Int J Mol Sci. 2019 Jun 22;20(12):
pubmed: 31234549
Molecules. 2018 Mar 02;23(3):
pubmed: 29498707
ACS Med Chem Lett. 2010 Jul 20;1(8):411-5
pubmed: 24900225
Biomolecules. 2020 Feb 14;10(2):
pubmed: 32075023
Bioorg Med Chem Lett. 2020 Nov 1;30(21):127493
pubmed: 32798652
Cold Spring Harb Perspect Biol. 2014 Apr 01;6(4):a018713
pubmed: 24691964
Pharmaceuticals (Basel). 2011 Dec 14;4(12):1578-1590
pubmed: 27721337
J Comput Aided Mol Des. 2013 Mar;27(3):221-34
pubmed: 23579614
EMBO Mol Med. 2019 Sep;11(9):e9854
pubmed: 31368626
Int J Mol Sci. 2018 Sep 27;19(10):
pubmed: 30262728
Int J Mol Sci. 2019 Dec 09;20(24):
pubmed: 31835389
Int J Mol Sci. 2019 Mar 05;20(5):
pubmed: 30841513
Clin Epigenetics. 2010 Sep;1(1-2):13-24
pubmed: 22704086
Nutrients. 2016 Jun 21;8(6):
pubmed: 27338466
Antibiotics (Basel). 2015 Jan 12;4(1):44-61
pubmed: 27025614
Cancers (Basel). 2019 Sep 07;11(9):
pubmed: 31500290
Cancers (Basel). 2019 Mar 05;11(3):
pubmed: 30841549
Expert Opin Investig Drugs. 2007 Jul;16(7):1111-20
pubmed: 17594194
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Clin Pharmacol. 2016 May 06;8:35-44
pubmed: 27226735
Int J Mol Sci. 2015 Oct 10;16(10):23994-4010
pubmed: 26473836
Chem Biodivers. 2021 Jan;18(1):e2000733
pubmed: 33236468
Curr Med Chem. 2020;27(15):2449-2493
pubmed: 30332940
Molecules. 2019 May 31;24(11):
pubmed: 31151320
Int J Mol Sci. 2015 May 19;16(5):11482-99
pubmed: 25997003
Int J Mol Sci. 2018 Dec 28;20(1):
pubmed: 30597863
Future Sci OA. 2018 Jul 27;4(8):FSO325
pubmed: 30271613
Cells. 2018 Dec 22;8(1):
pubmed: 30583560
Int J Mol Sci. 2018 Aug 09;19(8):
pubmed: 30096875
Int J Mol Sci. 2017 May 12;18(5):
pubmed: 28498322
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Cells. 2019 Nov 21;8(12):
pubmed: 31766421
Int J Mol Sci. 2019 Mar 16;20(6):
pubmed: 30884785
Int J Mol Sci. 2019 Sep 01;20(17):
pubmed: 31480543
Mediators Inflamm. 2017;2017:2608605
pubmed: 28127155
Int J Cardiol. 2016 Sep 15;219:396-403
pubmed: 27362830
Diseases. 2019 Nov 01;7(4):
pubmed: 31683808
Viruses. 2019 May 10;11(5):
pubmed: 31083335
Int J Mol Sci. 2019 Apr 16;20(8):
pubmed: 31014028
Int J Med Sci. 2019 Jan 29;16(3):424-442
pubmed: 30911277
PLoS One. 2014 Sep 03;9(9):e106186
pubmed: 25184280
Nutrients. 2014 Oct 15;6(10):4273-301
pubmed: 25322459
Med Sci (Basel). 2019 Mar 22;7(3):
pubmed: 30909413
Molecules. 2020 Feb 18;25(4):
pubmed: 32085499
Cancers (Basel). 2020 Jan 29;12(2):
pubmed: 32013157
Neuroimmunol Neuroinflamm. 2018;5:
pubmed: 30701185
Int J Mol Sci. 2018 Nov 09;19(11):
pubmed: 30424007
PLoS Biol. 2013 Nov;11(11):e1001717
pubmed: 24302884
Int J Mol Sci. 2017 May 01;18(5):
pubmed: 28468311
Exp Mol Med. 2020 Feb;52(2):204-212
pubmed: 32071378
Cancers (Basel). 2019 Apr 04;11(4):
pubmed: 30987296
Bioorg Med Chem Lett. 2008 Sep 15;18(18):5071-4
pubmed: 18723349
Pharmaceuticals (Basel). 2017 Apr 11;10(2):
pubmed: 28398261
Nutrients. 2018 Jun 06;10(6):
pubmed: 29882797
Curr Opin Struct Biol. 2011 Dec;21(6):735-43
pubmed: 21872466
Molecules. 2021 Feb 03;26(4):
pubmed: 33546456
Diseases. 2018 Jul 06;6(3):
pubmed: 29986388
Expert Opin Ther Pat. 2020 Apr;30(4):263-274
pubmed: 32008402
Nat Rev Genet. 2009 Jan;10(1):32-42
pubmed: 19065135
Oncol Rep. 2007 Oct;18(4):769-74
pubmed: 17786334
Future Med Chem. 2015;7(11):1367-71
pubmed: 26230876
Molecules. 2019 Mar 16;24(6):
pubmed: 30884859
J Comput Aided Mol Des. 2010 Jun;24(6-7):591-604
pubmed: 20354892
J Cell Mol Med. 2012 Aug;16(8):1758-65
pubmed: 22004558
Genet Mol Biol. 2013 Sep;36(3):299-307
pubmed: 24130434
Int J Mol Sci. 2019 Jul 02;20(13):
pubmed: 31269745
Drug News Perspect. 2009 Nov;22(9):513-24
pubmed: 20072728
Drug Saf. 2019 Feb;42(2):235-245
pubmed: 30649740
Cell Res. 2007 Mar;17(3):195-211
pubmed: 17325692
Pharmaceuticals (Basel). 2010 Aug 26;3(9):2751-2767
pubmed: 27713375
J Comput Aided Mol Des. 2007 Dec;21(12):681-91
pubmed: 17899391
Molecules. 2015 Mar 02;20(3):3898-941
pubmed: 25738536
Viruses. 2016 Jan 06;8(1):
pubmed: 26751469
Exp Ther Med. 2019 Aug;18(2):1057-1068
pubmed: 31363365
Nat Rev Drug Discov. 2007 Jan;6(1):21-2
pubmed: 17269160
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14639-44
pubmed: 20679231
J Med Chem. 2004 Mar 25;47(7):1750-9
pubmed: 15027866
Int J Mol Sci. 2017 Jul 01;18(7):
pubmed: 28671573
Int J Mol Sci. 2017 Jun 29;18(7):
pubmed: 28661460
Epigenomics. 2015;7(1):103-18
pubmed: 25687470
Cancers (Basel). 2019 Nov 14;11(11):
pubmed: 31739588
Bioorg Med Chem Lett. 2018 Feb 15;28(4):618-625
pubmed: 29395971