ADMET analysis
Alzheimer’s disease
BACE1
Neuro2a/APPSwe
amyloid precursor protein
molecular docking
neuritogenesis
neurodegenerative diseases
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
04 Sep 2021
04 Sep 2021
Historique:
received:
09
08
2021
revised:
26
08
2021
accepted:
31
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is implicated in the imbalance of several proteins, including Amyloid-β (Aβ), amyloid precursor protein (APP), and BACE1. APP overexpression interferes with neurite outgrowth, while BACE1 plays a role in Aβ generation. Medicinal herbs with effects on neurite outgrowth stimulation and BACE1 inhibition may benefit AD. This study aimed to investigate the neurite outgrowth stimulatory effect, along with BACE1 inhibition of
Identifiants
pubmed: 34577601
pii: ph14090901
doi: 10.3390/ph14090901
pmc: PMC8469274
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Chulalongkorn University
ID : GCUGR1125612058D
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