In Vitro and In Vivo Evaluation of Oral Controlled Release Formulation of BCS Class I Drug Using Polymer Matrix System.
controlled release
diltiazem hydrochloride
matrix system
poloxamer-188
polymer
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
16 Sep 2021
16 Sep 2021
Historique:
received:
09
08
2021
revised:
10
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism in the liver can limit the bioavailability and increase the dose frequencies for up to four times per day. This study focused on a polymer matrix system not only to control the drug release but also to prolong the duration of bioavailability. The polymer matrices were prepared using different ratios of poloxamer-188, hydroxypropyl methylcellulose, and stearyl alcohol. In vitro and in vivo assessments took place using 24 rabbits and the results were compared to commercially available product Tildiem
Identifiants
pubmed: 34577629
pii: ph14090929
doi: 10.3390/ph14090929
pmc: PMC8470007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : College of Medicine and Health Sciences, United Arab Emirates University
ID : Research Start- up grant no: 700032854
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