The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.
ES-2
HO-3867
OVCAR3
ovarian cancer
p53
placenta-specific protein 1 (PLAC1)
reactivator
steric hindrance
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
20
07
2021
revised:
06
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer. Recent studies have shown that the tumor suppressor p53 directly suppresses PLAC1 transcription. However, mutations in p53 lead to the loss of PLAC1 transcriptional suppression. Small molecules that structurally convert mutant p53 proteins to wild-type conformations are emerging. Our objective was to determine whether the restoration of the wild-type function of mutated p53 could rescue PLAC1 transcriptional suppression in tumors harboring certain
Identifiants
pubmed: 34577642
pii: ph14090942
doi: 10.3390/ph14090942
pmc: PMC8465575
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : R01CA99908
Pays : United States
Organisme : NIH HHS
ID : R01CA184101
Pays : United States
Organisme : NIH HHS
ID : NIH32HL007101
Pays : United States
Organisme : ABOG/AAOGF
ID : Bridge Funding Award
Organisme : NCI NIH HHS
ID : P30CA086862
Pays : United States
Organisme : University of Iowa Department of Obstetrics and Gynecology Research Development Fund
ID : NA
Organisme : CCKMA
ID : Iowa cancer patient advocacy group
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