Lassa Fever Virus Binds Matriglycan-A Polymer of Alternating Xylose and Glucuronate-On α-Dystroglycan.
Axl
Gas6
LARGE1
Lassa fever virus
apoptotic mimicry
dystrophin-glycoprotein complex
laminin
lymphocytic choriomeningitis
matriglycan
α-dystroglycan
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
received:
21
07
2021
revised:
18
08
2021
accepted:
20
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Lassa fever virus (LASV) can cause life-threatening hemorrhagic fevers for which there are currently no vaccines or targeted treatments. The late Prof. Stefan Kunz, along with others, showed that the high-affinity host receptor for LASV, and other Old World and clade-C New World mammarenaviruses, is matriglycan-a linear repeating disaccharide of alternating xylose and glucuronic acid that is polymerized uniquely on α-dystroglycan by like-acetylglucosaminyltransferase-1 (LARGE1). Although α-dystroglycan is ubiquitously expressed, LASV preferentially infects vascular endothelia and professional phagocytic cells, which suggests that viral entry requires additional cell-specific factors. In this review, we highlight the work of Stefan Kunz detailing the molecular mechanism of LASV binding and discuss the requirements of receptors, such as tyrosine kinases, for internalization through apoptotic mimicry.
Identifiants
pubmed: 34578260
pii: v13091679
doi: 10.3390/v13091679
pmc: PMC8473316
pii:
doi:
Substances chimiques
Polymers
0
Receptors, Virus
0
Dystroglycans
146888-27-9
Glucuronic Acid
8A5D83Q4RW
Xylose
A1TA934AKO
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P50 NS053672
Pays : United States
Organisme : Paul D. Wellstone Muscular Dystrophy Specialized Research Center grant
ID : 1U54NS053672
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