SARS-CoV-2 Infection Modulates ACE2 Function and Subsequent Inflammatory Responses in Swabs and Plasma of COVID-19 Patients.
SARS-CoV-2-ACE2
biomarker
inflammation
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 08 2021
28 08 2021
Historique:
received:
20
07
2021
revised:
23
08
2021
accepted:
25
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral infection to changes in ACE2 expression and function, which might influence the subsequent induction of an inflammatory response. Here, we tested the significance of soluble ACE2 enzymatic activity longitudinally in nasopharyngeal swabs and plasma samples of SARS-CoV-2 infected patients, along with the induction of inflammatory cytokines. Release of soluble functional ACE2 increases upon SARS-CoV-2 infection in swabs and plasma of infected patients, albeit rapidly decreasing during infection course in parallel with
Identifiants
pubmed: 34578296
pii: v13091715
doi: 10.3390/v13091715
pmc: PMC8471465
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI17/00624, PI19/00194,CPII19/00012
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : LG
Références
J Virol. 2014 Jan;88(2):1293-307
pubmed: 24227843
J Biol Chem. 2005 Aug 26;280(34):30113-9
pubmed: 15983030
Front Physiol. 2021 May 28;12:653045
pubmed: 34122129
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
FASEB J. 2021 Aug;35(8):e21745
pubmed: 34191346
Lancet Infect Dis. 2020 Oct;20(10):1135-1140
pubmed: 32526193
Lancet Respir Med. 2020 Nov;8(11):1154-1158
pubmed: 33131609
Atherosclerosis. 2016 Oct;253:135-143
pubmed: 27615597
Cardiovasc Pathol. 2013 Jan-Feb;22(1):42-8
pubmed: 22749485
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Lancet. 2020 Oct 3;396(10256):968-976
pubmed: 33010842
Nephrol Dial Transplant. 2015 Jul;30(7):1176-85
pubmed: 25813276
Eur Respir J. 2021 May 13;57(5):
pubmed: 33479113
Cell. 2020 May 28;181(5):1016-1035.e19
pubmed: 32413319
J Exp Med. 2020 Aug 3;217(8):
pubmed: 32556101
Eur Heart J. 2020 May 14;41(19):1810-1817
pubmed: 32388565
J Gen Virol. 2012 Sep;93(Pt 9):1924-1929
pubmed: 22718567
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Circ Res. 2000 Sep 1;87(5):E1-9
pubmed: 10969042
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
Front Pediatr. 2020 Apr 23;8:206
pubmed: 32391299
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32706339
PLoS Biol. 2020 Sep 8;18(9):e3000849
pubmed: 32898168
Int J Infect Dis. 2021 Feb;103:412-414
pubmed: 33249290
Nat Genet. 2020 Dec;52(12):1283-1293
pubmed: 33077916
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
JACC Cardiovasc Imaging. 2020 Mar;13(3):655-664
pubmed: 31607667
Nephron Clin Pract. 2012;121(3-4):c144-50
pubmed: 23257682
Eur Respir J. 2020 May 14;55(5):
pubmed: 32217650
N Engl J Med. 2021 Feb 4;384(5):417-427
pubmed: 33289973
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
Annu Rev Microbiol. 2019 Sep 8;73:529-557
pubmed: 31226023
J Biol Chem. 2000 Oct 27;275(43):33238-43
pubmed: 10924499
PLoS One. 2021 Jun 4;16(6):e0252799
pubmed: 34086837
Hypertension. 2006 Nov;48(5):914-20
pubmed: 17000927
Lancet Infect Dis. 2020 Apr;20(4):410-411
pubmed: 32087116
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
J Card Fail. 2009 Sep;15(7):565-71
pubmed: 19700132
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Cell Mol Life Sci. 2010 Jan;67(1):89-98
pubmed: 19763395
J Med Virol. 2020 Nov;92(11):2693-2701
pubmed: 32497323