Genomic Instability and DNA Damage Repair Pathways Induced by Human Papillomaviruses.
APOBEC
DNA damage repair
HPV
mutations
oropharynx
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 09 2021
14 09 2021
Historique:
received:
15
07
2021
revised:
29
08
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Human papillomaviruses (HPV) are the causative agents of cervical and other anogenital cancers as well as those of the oropharynx. HPV proteins activate host DNA damage repair factors to promote their viral life cycle in stratified epithelia. Activation of both the ATR pathway and the ATM pathway are essential for viral replication and differentiation-dependent genome amplification. These pathways are also important for maintaining host genomic integrity and their dysregulation or mutation is often seen in human cancers. The APOBEC3 family of cytidine deaminases are innate immune factors that are increased in HPV positive cells leading to the accumulation of TpC mutations in cellular DNAs that contribute to malignant progression. The activation of DNA damage repair factors may corelate with expression of APOBEC3 in HPV positive cells. These pathways may actively drive tumor development implicating/suggesting DNA damage repair factors and APOBEC3 as possible therapeutic targets.
Identifiants
pubmed: 34578402
pii: v13091821
doi: 10.3390/v13091821
pmc: PMC8472259
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA059655
Pays : United States
Organisme : NCI NIH HHS
ID : RO1 CA 059655
Pays : United States
Organisme : NCI NIH HHS
ID : RO1 CA142861
Pays : United States
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