Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts.
HELIUS study
diabetes
ethnicity
gut microbiota
protein diet
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
02
08
2021
revised:
18
08
2021
accepted:
27
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition. To determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities. Separate cross-sectional analysis of two European cohorts (MetaCardis, In both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity. Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
Sections du résumé
BACKGROUND
BACKGROUND
Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition.
OBJECTIVES
OBJECTIVE
To determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities.
METHODS
METHODS
Separate cross-sectional analysis of two European cohorts (MetaCardis,
RESULTS
RESULTS
In both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity.
CONCLUSIONS
CONCLUSIONS
Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
Identifiants
pubmed: 34579043
pii: nu13093159
doi: 10.3390/nu13093159
pmc: PMC8465773
pii:
doi:
Substances chimiques
DNA, Bacterial
0
Dietary Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation Leducq
ID : 33.17CVD01
Organisme : Joint Programming Initiative A healthy diet for a healthy life
ID : 5290510105
Organisme : ZonMw
ID : 09150182010020
Pays : Netherlands
Organisme : Fondation pour la Recherche Médicale
ID : FDT202106012793
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