Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects.
Animals
Animals, Suckling
/ physiology
Caloric Restriction
/ adverse effects
Dietary Supplements
Female
Hypothalamus
/ chemistry
Inositol
/ administration & dosage
Lactation
/ physiology
Leptin
Leukocytes, Mononuclear
/ chemistry
Male
Pregnancy
Prenatal Exposure Delayed Effects
RNA, Messenger
/ analysis
Rats
Rats, Wistar
Receptors, Leptin
/ genetics
PBMC
arcuate nucleus
fetal undernutrition
lactation period
leptin
metabolic programming
myo-inositol
paraventricular nucleus
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Sep 2021
18 Sep 2021
Historique:
received:
27
07
2021
revised:
10
09
2021
accepted:
14
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
We studied whether myo-inositol supplementation throughout lactation, alone and combined with leptin, may reverse detrimental effects on hypothalamic structure and function caused by gestational calorie gestation (CR) in rats. Candidate early transcript-based biomarkers of metabolic health in peripheral blood mononuclear cells (PBMC) were also studied. Offspring of dams exposed to 25% gestational CR and supplemented during lactation with physiological doses of leptin (CR-L), myo-inositol (CR-M), the combination (CR-LM), or the vehicle (CR-V) as well as control rats (CON-V) were followed and sacrificed at postnatal day 25. Myo-inositol and the combination increased the number of neurons in arcuate nucleus (ARC) (only in females) and paraventricular nucleus, and myo-inositol (alone) restored the number of αMSH
Identifiants
pubmed: 34579137
pii: nu13093257
doi: 10.3390/nu13093257
pmc: PMC8466200
pii:
doi:
Substances chimiques
Leptin
0
RNA, Messenger
0
Receptors, Leptin
0
Inositol
4L6452S749
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Government (MCIU/AEI/FEDER, UE)
ID : PGC2018-097436-B-I00
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