Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials.
cancer
mortality
supplementation
survival
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
26
08
2021
revised:
16
09
2021
accepted:
17
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
30
9
2021
Statut:
epublish
Résumé
Several studies have investigated the beneficial effects of vitamin D on survival of cancer patients. Overall evidence has been accumulating with contrasting results. This paper aims at narratively reviewing the existing articles examining the link between vitamin D supplementation and cancer mortality. We performed two distinct searches to identify observational (ObS) studies and randomized clinical trials (RCTs) of vitamin D supplementation (VDS) in cancer patients and cohorts of general population, which included cancer mortality as an outcome. Published reports were gathered until March 2021. We identified 25 papers published between 2003 and 2020, including n. 8 RCTs on cancer patients, n. 8 population RCTs and n. 9 ObS studies. There was some evidence that the use of VDS in cancer patients could improve cancer survival, but no significant effect was found in population RCTs. Some ObS studies reported evidence that VDS was associated with a longer survival among cancer patients, and only one study found an opposite effect. The findings do not allow conclusive answers. VDS may have the potential as treatment to improve survival in cancer patients, but further investigations are warranted. We strongly support investment in well-designed and sufficiently powered RCTs to fully evaluate this association.
Identifiants
pubmed: 34579164
pii: nu13093285
doi: 10.3390/nu13093285
pmc: PMC8466115
pii:
doi:
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grant Regione Lombardia. (DECRETO N. 7082 Del 17/06/2020. Identificativo Atto n. 366: CO-Vi-taminD Trial: prevenzione di complicanze da COVID-19 in pazienti oncologici).
ID : 366
Organisme : Federica Bellerba is a Ph.D. student within the European School of Molecular Medicine (SEMM).
ID : NA
Organisme : Italian Ministry of Health with Ricerca Corrente and 5×1,000 funds.
ID : NA
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