Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis.

adult antibody response immune response immunogenicity inactivated influenza vaccine infant intranasal live attenuated influenza vaccine safety

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
07 Sep 2021
Historique:
received: 06 08 2021
revised: 31 08 2021
accepted: 03 09 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 29 9 2021
Statut: epublish

Résumé

Although influenza is a major public health concern, little is known about the use of spray live attenuated influenza vaccine (LAIV) among adults. For this reason, we conducted a systematic review and meta-analysis to investigate the efficacy and safety of LAIV, especially in adults with/without clinical conditions and children <2 years, with the final aim of possibly extending the clinical indications. PubMed/MEDLINE and Scopus were the two databases consulted through February 2021. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A critical appraisal was conducted. Analyses were performed by using ProMeta3 software. Twenty-two studies were included, showing that LAIV was associated with a higher probability of seroconversion when compared with a placebo and considering the A/H1N1 serotype (pooled OR = 2.26 (95% CI = 1.12-4.54),

Identifiants

pubmed: 34579235
pii: vaccines9090998
doi: 10.3390/vaccines9090998
pmc: PMC8472940
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Giulia Perego (G)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Giacomo Pietro Vigezzi (GP)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Giulia Cocciolo (G)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Federica Chiappa (F)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Stefano Salvati (S)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Federica Balzarini (F)

Dipartimento per la Programmazione, Accreditamento, Acquisto delle Prestazioni Sanitarie e Sociosanitarie (PAAPSS), Servizio Autorizzazione e Accreditamento, Agenzia di Tutela della Salute (ATS) di Bergamo, Via Galliccioli, 4, 24121 Bergamo, Italy.

Anna Odone (A)

Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.

Carlo Signorelli (C)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.

Vincenza Gianfredi (V)

School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.
CAPHRI Care and Public Health Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands.

Classifications MeSH