A Review on Coumarin Derivatives as Potent Anti-tuberculosis Agents.

Antitubercular Agents / chemistry Coumarins / chemistry Drug Design Extensively Drug-Resistant Tuberculosis / drug therapy Humans Mycobacterium tuberculosis
(SAR) for designing better anti-TB agents SAR Coumarin Mycobacterium tuberculosis anti-TB antitubercular synthesis tubercle bacillus

Journal

Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212

Informations de publication

Date de publication:
2022
Historique:
received: 04 12 2020
revised: 08 04 2021
accepted: 01 06 2021
pubmed: 29 9 2021
medline: 25 5 2022
entrez: 28 9 2021
Statut: ppublish

Résumé

Tuberculosis (TB) is an acute or chronic infectious disease caused by several species of Mycobacterium, collectively called tubercle bacilli or Mycobacterium tuberculosis complex. Around 10 million people get sick with tuberculosis (TB) each year. TB is the second leading cause of death today after HIV/AIDS. A serious problem in the context of MDR-TB is the extensively drug-resistant TB, which is an important reason for the restricted chemotherapy in TB. Therefore, there is a need to explore new antitubercular (anti-TB) agents. Coumarin is an oxygencontaining heterocyclic compound and can be widely found in many natural products, and many of them display diverse biological activities. The wide spectrum of activities of coumarin molecules has intrigued the scientists to explore the natural coumarins and their synthetic derivatives for their potential as anti-TB drugs. The objective of this review is to emphasize important coumarin analogs with anti-TB activities and their structure-activity relationships (SAR) for designing better anti-TB agents. Latest, authentic and published reports on various synthetic and natural coumarin derivatives and their anti-TB activities is being thoroughly studied and analyzed. The structural requirements of coumarins as anti-TB drugs have also been studied. Collection and compilation of reports on various synthetic and natural coumarin derivatives and their anti-TB activities are being performed. The study provides the latest report on coumarin derivatives synthesized as anti-TB agent and whether their activity depends on structural changes or not.

Sections du résumé

BACKGROUND BACKGROUND
Tuberculosis (TB) is an acute or chronic infectious disease caused by several species of Mycobacterium, collectively called tubercle bacilli or Mycobacterium tuberculosis complex. Around 10 million people get sick with tuberculosis (TB) each year. TB is the second leading cause of death today after HIV/AIDS. A serious problem in the context of MDR-TB is the extensively drug-resistant TB, which is an important reason for the restricted chemotherapy in TB. Therefore, there is a need to explore new antitubercular (anti-TB) agents. Coumarin is an oxygencontaining heterocyclic compound and can be widely found in many natural products, and many of them display diverse biological activities. The wide spectrum of activities of coumarin molecules has intrigued the scientists to explore the natural coumarins and their synthetic derivatives for their potential as anti-TB drugs.
OBJECTIVE OBJECTIVE
The objective of this review is to emphasize important coumarin analogs with anti-TB activities and their structure-activity relationships (SAR) for designing better anti-TB agents.
METHOD METHODS
Latest, authentic and published reports on various synthetic and natural coumarin derivatives and their anti-TB activities is being thoroughly studied and analyzed. The structural requirements of coumarins as anti-TB drugs have also been studied.
RESULT RESULTS
Collection and compilation of reports on various synthetic and natural coumarin derivatives and their anti-TB activities are being performed.
CONCLUSION CONCLUSIONS
The study provides the latest report on coumarin derivatives synthesized as anti-TB agent and whether their activity depends on structural changes or not.

Identifiants

DOI: 10.2174/1389557521666210927124511 PMID: 34579635
pubmed: 34579635
pii: MRMC-EPUB-118194
doi: 10.2174/1389557521666210927124511
doi:

Substances chimiques

Antitubercular Agents 0
Coumarins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1064-1080

Subventions

Organisme : research and development, Integral University, Lucknow, India.
ID : IU/R&D/2020-MCN000819

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Samar Mujeeb (S)

Faculty of Pharmacy, Integral University, Kursi road, Lucknow 226026 (U.P.), India.
Hygia Institute Of Pharmaceutical Education And Research, Lucknow, India.

Kuldeep Singh (K)

Faculty of Pharmacy, Integral University, Kursi road, Lucknow 226026 (U.P.), India.

Bhumika Yogi (B)

Hygia Institute Of Pharmaceutical Education And Research, Lucknow, India.

Vaseem Ansari (V)

Faculty of Pharmacy, Integral University, Kursi road, Lucknow 226026 (U.P.), India.

Shweta Sinha (S)

Goel Institute of Pharmaceutical Sciences, Lucknow -226028 (U.P.), India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › A Review on Coumarin Derivatives as Potent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › A Review on Coumarin Derivatives as Potent...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › A Review on Coumarin Derivatives as Potent...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › Tuberculose ultrarésistante aux médicaments › A Review on Coumarin Derivatives as Potent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Review on Coumarin Derivatives as Potent...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › A Review on Coumarin Derivatives as Potent...