Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
received:
06
08
2021
revised:
10
09
2021
accepted:
23
09
2021
pubmed:
29
9
2021
medline:
7
1
2022
entrez:
28
9
2021
Statut:
ppublish
Résumé
Aberrant cell fate decisions due to transcriptional misregulation are central to malignant transformation. Histones are the major constituents of chromatin, and mutations in histone-encoding genes are increasingly recognized as drivers of oncogenic transformation. Mutations in linker histone H1 genes were recently identified as drivers of peripheral lymphoid malignancy. Loss of H1 in germinal center B cells results in widespread chromatin decompaction, redistribution of core histone modifications, and reactivation of stem cell-specific transcriptional programs. This review explores how linker histones and mutations therein regulate chromatin structure, highlighting reciprocal relationships between epigenetic circuits, and discusses the emerging role of aberrant three-dimensional chromatin architecture in malignancy.
Identifiants
pubmed: 34580064
pii: 0008-5472.CAN-21-2619
doi: 10.1158/0008-5472.CAN-21-2619
pmc: PMC8678342
mid: NIHMS1745317
doi:
Substances chimiques
Histones
0
nuclear protein H1(0)
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6061-6070Subventions
Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220499
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA229086
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM040922
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204639
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA234561
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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