Calcium-based nanomaterials and their interrelation with chitosan: optimization for pCRISPR delivery.
Calcium-based non-viral vector
Chitosan-based nanomaterials
Gene delivery
pCRISPR
Journal
Journal of nanostructure in chemistry
ISSN: 2008-9244
Titre abrégé: J Nanostructure Chem
Pays: Germany
ID NLM: 101684961
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
04
2021
accepted:
03
09
2021
pubmed:
29
9
2021
medline:
29
9
2021
entrez:
28
9
2021
Statut:
ppublish
Résumé
There have been numerous advancements in the early diagnosis, detection, and treatment of genetic diseases. In this regard, CRISPR technology is promising to treat some types of genetic issues. In this study, the relationship between calcium (due to its considerable physicochemical properties) and chitosan (as a natural linear polysaccharide) was investigated and optimized for pCRISPR delivery. To achieve this, different forms of calcium, such as calcium nanoparticles (CaNPs), calcium phosphate (CaP), a binary blend of calcium and chitosan including CaNPs/Chitosan and CaP/Chitosan, as well as their tertiary blend including CaNPs-CaP/Chitosan, were prepared via both routine and green procedures using The online version contains supplementary material available at 10.1007/s40097-021-00446-1.
Identifiants
pubmed: 34580605
doi: 10.1007/s40097-021-00446-1
pii: 446
pmc: PMC8457547
doi:
Types de publication
Journal Article
Langues
eng
Pagination
919-932Informations de copyright
© Islamic Azad University 2021.
Déclaration de conflit d'intérêts
Conflict of interestsThe authors declare that they have no conflicts of interest with the present study.
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