Screening paracoccidioidomycosis by double immunodiffusion test in a referred diagnostic center in Brazilian southeastern: an accessible tool.
Diagnosis
Paracoccidioidomycosis
Serology
Systemic infection, mycosis, double immunodiffusion test
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
18
02
2021
accepted:
20
09
2021
pubmed:
29
9
2021
medline:
27
11
2021
entrez:
28
9
2021
Statut:
ppublish
Résumé
This article shows reports of the clinical-epidemiological characteristics and serological screening in patients assisted by a reference center for PCM care, University Hospital Cassiano Antonio Moraes, Federal University of Espirito Santo, Brazil. The patient's sera with PCM were analyzed by DID test at the beginning and the end treatment. Clinical and demographic data were also collected to characterize the sample. One hundred patients with a suspected diagnosis of PCM were evaluated. Serology by DID test was used as a screen in all patients. The test was positive for 79 patients (72 for Paracoccidioides brasiliensis and 7 for Paracoccidioides lutzii). Serology was negative in 21 sera, although all of them were diagnosed PCM by histopathologic or direct exam. Serological follow-up was performed during the treatment of all patients. After treatment, 58(58%) had negative serology and 33(33%) low levels of antibodies (≤ 1:16). Our results indicate the importance of the DID test for the screening and monitoring of PCM and that the incidence of P. lutzii might be greater than expected in areas where it is not the predominant PCM species. Therefore, this article may contribute to improving the knowledge and clinical management about this disease.
Identifiants
pubmed: 34580797
doi: 10.1007/s15010-021-01704-8
pii: 10.1007/s15010-021-01704-8
doi:
Substances chimiques
Antigens, Fungal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1257-1264Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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