Multiscale Biology of Cardiovascular Risk in Psoriasis: Protocol for a Case-Control Study.
bioinformatics
cardiovascular disease
cardiovascular imaging
lipidomics
mass cytometry
microbiome
proteomics
psoriasis
study protocol
system biology
Journal
JMIR research protocols
ISSN: 1929-0748
Titre abrégé: JMIR Res Protoc
Pays: Canada
ID NLM: 101599504
Informations de publication
Date de publication:
28 Sep 2021
28 Sep 2021
Historique:
received:
10
03
2021
accepted:
25
08
2021
revised:
17
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Patients with psoriasis have increased risk of cardiovascular disease (CVD) independent of traditional risk factors. The molecular mechanisms underlying the psoriasis-CVD connection are not fully understood. Advances in high-throughput molecular profiling technologies and computational analysis techniques offer new opportunities to improve the understanding of disease connections. We aim to characterize the complexity of cardiovascular risk in patients with psoriasis by integrating deep phenotypic data with systems biology techniques to perform comprehensive multiomic analyses and construct network models of the two interacting diseases. The study aims to include 120 adult patients with psoriasis (60 with prior atherosclerotic CVD and 60 without CVD). Half of the patients are already receiving systemic antipsoriatic treatment. All patients complete a questionnaire, and a medical interview is conducted to collect medical history and information on, for example, socioeconomics, mental health, diet, and physical exercise. Participants are examined clinically with assessment of the Psoriasis Area and Severity Index and undergo imaging by transthoracic echocardiography, Recruitment was completed in September 2020. Preliminary results of This systems biology approach with integration of multiomics and clinical data in patients with psoriasis with or without CVD is likely to provide novel insights into the biological mechanisms underlying these diseases and their interplay that can impact future treatment. DERR1-10.2196/28669.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with psoriasis have increased risk of cardiovascular disease (CVD) independent of traditional risk factors. The molecular mechanisms underlying the psoriasis-CVD connection are not fully understood. Advances in high-throughput molecular profiling technologies and computational analysis techniques offer new opportunities to improve the understanding of disease connections.
OBJECTIVE
OBJECTIVE
We aim to characterize the complexity of cardiovascular risk in patients with psoriasis by integrating deep phenotypic data with systems biology techniques to perform comprehensive multiomic analyses and construct network models of the two interacting diseases.
METHODS
METHODS
The study aims to include 120 adult patients with psoriasis (60 with prior atherosclerotic CVD and 60 without CVD). Half of the patients are already receiving systemic antipsoriatic treatment. All patients complete a questionnaire, and a medical interview is conducted to collect medical history and information on, for example, socioeconomics, mental health, diet, and physical exercise. Participants are examined clinically with assessment of the Psoriasis Area and Severity Index and undergo imaging by transthoracic echocardiography,
RESULTS
RESULTS
Recruitment was completed in September 2020. Preliminary results of
CONCLUSIONS
CONCLUSIONS
This systems biology approach with integration of multiomics and clinical data in patients with psoriasis with or without CVD is likely to provide novel insights into the biological mechanisms underlying these diseases and their interplay that can impact future treatment.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
UNASSIGNED
DERR1-10.2196/28669.
Identifiants
pubmed: 34581684
pii: v10i9e28669
doi: 10.2196/28669
pmc: PMC8512189
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e28669Informations de copyright
©Hannah Kaiser, Amanda Kvist-Hansen, Christine Becker, Xing Wang, Benjamin D McCauley, Martin Krakauer, Peter Michael Gørtz, Kristoffer Mads Aaris Henningsen, Claus Zachariae, Lone Skov, Peter Riis Hansen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 28.09.2021.
Références
Nat Rev Cardiol. 2021 May;18(5):313-330
pubmed: 33340009
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
JAMA Dermatol. 2013 Oct;149(10):1173-9
pubmed: 23925466
Brief Bioinform. 2018 Nov 27;19(6):1370-1381
pubmed: 28679163
Dermatology. 2005;210(3):194-9
pubmed: 15785046
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Cytometry A. 2015 Jul;87(7):636-45
pubmed: 25573116
JACC Basic Transl Sci. 2017 Jun 26;2(3):311-327
pubmed: 30062151
Nucleic Acids Res. 2012 Sep 1;40(17):e133
pubmed: 22638577
Cerebrovasc Dis. 2012;34(4):290-6
pubmed: 23128470
Nat Rev Microbiol. 2018 Mar;16(3):143-155
pubmed: 29332945
Life (Basel). 2021 Apr 01;11(4):
pubmed: 33915972
N Engl J Med. 2009 Jul 30;361(5):496-509
pubmed: 19641206
PLoS One. 2014 Apr 22;9(4):e95192
pubmed: 24755770
Eur Heart J Cardiovasc Imaging. 2013 Jul;14(7):625-30
pubmed: 23539476
J Oral Pathol Med. 2019 May;48(5):365-372
pubmed: 30739339
J Am Heart Assoc. 2013 Apr 04;2(2):e000062
pubmed: 23557749
Acta Derm Venereol. 2021 Feb 24;101(2):adv00406
pubmed: 33491097
J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1128-34
pubmed: 25303139
Circulation. 2007 Jan 23;115(3):402-26
pubmed: 17220398
BMC Syst Biol. 2019 Jan 14;13(1):8
pubmed: 30642337
J Proteome Res. 2019 Feb 1;18(2):623-632
pubmed: 30450911
Atherosclerosis. 2014 Dec;237(2):499-503
pubmed: 25463081
Genome Biol. 2014;15(12):550
pubmed: 25516281
J Am Acad Dermatol. 2017 Mar;76(3):377-390
pubmed: 28212759
Cell. 2016 May 5;165(4):780-91
pubmed: 27153492
Anal Chem. 2009 Aug 15;81(16):6656-67
pubmed: 19624122
Front Genet. 2019 Jun 12;10:535
pubmed: 31249591
Atherosclerosis. 2015 Sep;242(1):205-10
pubmed: 26204497
Nucleic Acids Res. 2011 Aug;39(15):e102
pubmed: 21646338
J Am Acad Dermatol. 2005 Feb;52(2):262-7
pubmed: 15692471
Arthritis Rheum. 2007 Mar 15;57(2):287-93
pubmed: 17330278
JAMA. 2006 Oct 11;296(14):1735-41
pubmed: 17032986
Br J Dermatol. 2008 Aug;159 Suppl 2:10-7
pubmed: 18700910
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
J Am Coll Cardiol. 1990 Mar 15;15(4):827-32
pubmed: 2407762
Nat Biotechnol. 2018 Dec 03;:
pubmed: 30531897
Nat Biotechnol. 2017 Sep 12;35(9):833-844
pubmed: 28898207
Curr Protoc Cytom. 2010 Jul;Chapter 10:Unit10.17
pubmed: 20578106
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Nat Rev Genet. 2016 Oct;17(10):615-29
pubmed: 27498692
Br J Dermatol. 2009 Jul;161(1):1-7
pubmed: 19500102
Anal Chim Acta. 2021 Jan 2;1141:144-162
pubmed: 33248648
Nat Immunol. 2014 Feb;15(2):118-27
pubmed: 24448569
Genome Biol. 2019 Nov 28;20(1):257
pubmed: 31779668
Trends Mol Med. 2020 Aug;26(8):718-728
pubmed: 32439301
Sci Rep. 2017 Aug 18;7(1):8707
pubmed: 28821884
J Am Soc Echocardiogr. 2009 Dec;22(12):1311-9; quiz 1417-8
pubmed: 19944955
Eur J Nucl Med Mol Imaging. 2016 Apr;43(4):780-92
pubmed: 26678270
Sci Transl Med. 2015 Oct 28;7(311):311ra174
pubmed: 26511511