A comprehensive review of COVID-19 biology, diagnostics, therapeutics, and disease impacting the central nervous system.
CNS
COVID-19
Coronavirus
SARS-CoV-2
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
11
02
2021
accepted:
01
07
2021
revised:
17
05
2021
pubmed:
29
9
2021
medline:
25
11
2021
entrez:
28
9
2021
Statut:
ppublish
Résumé
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly transmissible disease. SARS-CoV-2 is estimated to have infected over 153 million people and to have caused over 3.2 million global deaths since its emergence in December 2019. SARS-CoV-2 is the seventh coronavirus known to infect humans, and like other coronaviruses, SARS-CoV-2 infection is characterized by a variety of symptoms including general flu-like symptoms such as a fever, sore throat, fatigue, and shortness of breath. Severe cases often display signs of pneumonia, lymphopenia, acute kidney injury, cardiac injury, cytokine storms, lung damage, acute respiratory distress syndrome (ARDS), multiple organ failure, sepsis, and death. There is evidence that around 30% of COVID-19 cases have central nervous system (CNS) or peripheral nervous system (PNS) symptoms along with or in the absence of the previously mentioned symptoms. In cases of CNS/PNS impairments, patients display dizziness, ataxia, seizure, nerve pain, and loss of taste and/or smell. This review highlights the neurological implications of SARS-CoV-2 and provides a comprehensive summary of the research done on SARS-CoV-2 pathology, diagnosis, therapeutics, and vaccines up to May 5.
Identifiants
pubmed: 34581996
doi: 10.1007/s13365-021-00998-6
pii: 10.1007/s13365-021-00998-6
pmc: PMC8477646
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-690Subventions
Organisme : NIAID NIH HHS
ID : R21 AI074410
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI078859
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI043894
Pays : United States
Organisme : NIH HHS
ID : AI078859, AI074410, AI127351-01, AI043894, NS099029
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127351
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099029
Pays : United States
Informations de copyright
© 2021. Journal of NeuroVirology, Inc.
Références
Gastroenterologe. 2020 Oct 29;:1-7
pubmed: 33144889
Expert Rev Vaccines. 2010 Mar;9(3):309-21
pubmed: 20218859
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Signal Transduct Target Ther. 2021 Apr 24;6(1):169
pubmed: 33895780
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
J Comp Neurol. 2013 Jan 1;521(1):203-12
pubmed: 22700307
Lancet Respir Med. 2020 Dec;8(12):1192-1200
pubmed: 33038974
J Neurol. 2020 Jul;267(7):1880-1882
pubmed: 32361836
EMBO J. 2020 Oct 15;39(20):e106230
pubmed: 32876341
J Med Virol. 2020 Jun;92(6):552-555
pubmed: 32104915
Stem Cells. 2016 Feb;34(2):380-91
pubmed: 26523849
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Adv Drug Deliv Rev. 2021 Mar;170:1-25
pubmed: 33359141
Int J Mol Sci. 2020 Nov 07;21(21):
pubmed: 33171852
Blood. 2014 Jul 10;124(2):188-95
pubmed: 24876563
J Neuroimmune Pharmacol. 2020 Sep;15(3):520-537
pubmed: 31338754
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8089-8094
pubmed: 28696292
Sensors (Basel). 2020 Oct 03;20(19):
pubmed: 33023039
Eur J Cell Biol. 2003 Feb;82(2):53-73
pubmed: 12647932
Emerg Infect Dis. 2019 Jan;25(1):1-4
pubmed: 30560777
Electrophoresis. 2020 Mar;41(5-6):319-327
pubmed: 31850534
Front Immunol. 2020 Apr 24;11:879
pubmed: 32391022
Int J Antimicrob Agents. 2020 May;55(5):105954
pubmed: 32234467
J Chin Med Assoc. 2005 Mar;68(3):106-7
pubmed: 15813242
Cell Host Microbe. 2016 Feb 10;19(2):181-93
pubmed: 26867177
Eur J Clin Microbiol Infect Dis. 2005 Jan;24(1):44-6
pubmed: 15616839
Mil Med Res. 2020 Mar 13;7(1):11
pubmed: 32169119
FEBS Lett. 2002 Dec 4;532(1-2):107-10
pubmed: 12459472
Cell. 2021 Jan 21;184(2):460-475.e21
pubmed: 33278358
J Med Virol. 2020 Jun;92(6):595-601
pubmed: 32100877
Biomed Res Int. 2020 Nov 25;2020:2054376
pubmed: 33274196
Obesity (Silver Spring). 2020 May;28(5):848
pubmed: 32237199
Cell Reprogram. 2018 Jun;20(3):178-186
pubmed: 29782191
J Cell Physiol. 2019 Dec;234(12):23763-23773
pubmed: 31173364
J Cell Biochem. 2007 Aug 1;101(5):1278-91
pubmed: 17340620
ACS Chem Neurosci. 2020 Dec 16;11(24):4017-4020
pubmed: 33275404
Cell Res. 2020 Mar;30(3):269-271
pubmed: 32020029
Nat Commun. 2020 May 4;11(1):2251
pubmed: 32366817
Bioinform Biol Insights. 2020 Oct 21;14:1177932220965505
pubmed: 33149560
ACS Chem Neurosci. 2020 Sep 16;11(18):2793-2803
pubmed: 32845609
Viruses. 2018 Feb 24;10(2):
pubmed: 29495250
Antiviral Res. 2020 May;177:104762
pubmed: 32147496
CNS Neurosci Ther. 2018 May;24(5):429-438
pubmed: 29352519
Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L269-74
pubmed: 21665960
Brain Behav Immun. 2016 Aug;56:230-45
pubmed: 27033633
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
ACS Cent Sci. 2020 Mar 25;6(3):315-331
pubmed: 32226821
Nanomicro Lett. 2021;13(1):18
pubmed: 33163530
J Med Virol. 2021 May;93(5):2555-2556
pubmed: 33095459
J Virol. 2005 Feb;79(3):1635-44
pubmed: 15650189
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
Nat Biotechnol. 2020 Jul;38(7):870-874
pubmed: 32300245
Stem Cells. 2017 Apr;35(4):851-858
pubmed: 28294454
Crit Care Med. 2017 Feb;45(2):e202-e212
pubmed: 27861182
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
Ann Clin Transl Neurol. 2021 May;8(5):1073-1085
pubmed: 33755344
Respirology. 2006 Nov;11(6):715-22
pubmed: 17052299
Inflamm Allergy Drug Targets. 2014;13(4):224-34
pubmed: 25019157
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
Neurochem Int. 2018 Mar;114:55-57
pubmed: 29353063
Int J Antimicrob Agents. 2020 Mar;55(3):105924
pubmed: 32081636
J Med Virol. 2004 Sep;74(1):1-7
pubmed: 15258961
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Eur J Health Econ. 2020 Aug;21(6):817-823
pubmed: 32500243
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
Best Pract Res Clin Rheumatol. 2012 Feb;26(1):157-65
pubmed: 22424201
Can J Cardiol. 2020 May;36(5):784.e1-784.e2
pubmed: 32299780
J Microbiol Biotechnol. 2020 Mar 28;30(3):313-324
pubmed: 32238757
Sci Rep. 2017 Nov 6;7(1):14608
pubmed: 29097816
Curr Clin Pharmacol. 2018;13(2):85-99
pubmed: 28799485
Med Hypotheses. 2020 Nov;144:110271
pubmed: 33254575
Ecancermedicalscience. 2020 Mar 30;14:1023
pubmed: 32256706
J Pathol. 2003 Jul;200(3):282-9
pubmed: 12845623
J Neurol Sci. 2012 Feb 15;313(1-2):167-77
pubmed: 21962795
Cell Death Dis. 2016 Jan 21;7:e2062
pubmed: 26794657
Mol Med Rep. 2020 Nov;22(5):4221-4226
pubmed: 33000221
Thorax. 2014 Sep;69(9):819-25
pubmed: 24891325
J Affect Disord. 2020 Dec 1;277:337-340
pubmed: 32858315
Sci Rep. 2017 Jan 04;7:39889
pubmed: 28051154
Neural Regen Res. 2020 Dec;15(12):2217-2234
pubmed: 32594033
J Infect Dis. 2004 Sep 15;190(6):1119-26
pubmed: 15319862
Clin Infect Dis. 2005 Oct 15;41(8):1089-96
pubmed: 16163626
J Exp Med. 2005 Aug 1;202(3):415-24
pubmed: 16043521
Emerg Microbes Infect. 2020 Dec;9(1):761-770
pubmed: 32228226
JAMA. 2020 Apr 28;323(16):1582-1589
pubmed: 32219428
Expert Opin Biol Ther. 2009 Mar;9(3):355-68
pubmed: 19216624
J Virol. 2014 Oct;88(19):11297-303
pubmed: 25031349
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
Scand J Immunol. 1991 Jun;33(6):737-48
pubmed: 1675482
J Med Virol. 2020 May;92(5):491-494
pubmed: 32056249
Ann Intern Med. 2006 Oct 17;145(8):599-609
pubmed: 16940336
Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950
pubmed: 32301284
J Clin Microbiol. 2007 Mar;45(3):1049-52
pubmed: 17229859
Ear Nose Throat J. 2021 Apr;100(2_suppl):169S-173S
pubmed: 33236918
J Pathol. 2015 Jan;235(2):185-95
pubmed: 25270030
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
Front Immunol. 2020 Jul 10;11:1708
pubmed: 32754163
Med Hypotheses. 2020 Nov;144:110155
pubmed: 33254482
J Pathol. 2004 Jun;203(2):622-30
pubmed: 15141376
Int J Infect Dis. 2020 Nov;100:112-116
pubmed: 32891737
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
Chest. 2013 Aug;144(2):464-473
pubmed: 23450336
Sci Rep. 2017 Apr 10;7:46243
pubmed: 28393932
Mini Rev Med Chem. 2021;21(6):704-723
pubmed: 33185159
Eur J Dent. 2020 Dec;14(S 01):S152-S158
pubmed: 33242917
Basic Clin Pharmacol Toxicol. 2021 Feb;128(2):204-212
pubmed: 33176395
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Neurotox Res. 2020 Jun;38(1):1-7
pubmed: 32399719
Cells. 2020 Oct 30;9(11):
pubmed: 33143316
Nature. 2013 Mar 14;495(7440):251-4
pubmed: 23486063
Int J Biol Sci. 2020 Mar 15;16(10):1718-1723
pubmed: 32226289
Cancer Treat Rev. 2018 Feb;63:40-47
pubmed: 29207310
J Epidemiol Community Health. 2020 Nov 28;:
pubmed: 33249407
J Infect Chemother. 2021 Feb;27(2):406-409
pubmed: 33183963
FASEB J. 2007 Dec;21(14):3904-16
pubmed: 17628015
Mol Neurobiol. 2019 Dec;56(12):8157-8167
pubmed: 31197655
PLoS Med. 2006 Jul;3(7):e237
pubmed: 16796401
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
J Virol. 2013 Jun;87(12):6604-14
pubmed: 23552422
Med Hypotheses. 2020 Aug;141:109757
pubmed: 32344276
Ann Intern Med. 2020 Aug 18;173(4):268-277
pubmed: 32374815
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16357-62
pubmed: 19721001
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
Clin Microbiol Infect. 2004 Jul;10(7):676-8
pubmed: 15214887
Biosens Bioelectron. 2020 Dec 1;169:112643
pubmed: 33007615
Viruses. 2019 Dec 03;11(12):
pubmed: 31817037
Pathol Res Pract. 2020 Oct;216(10):153222
pubmed: 32979742
Paediatr Respir Rev. 2004 Dec;5(4):262-9
pubmed: 15531249
J Biomed Opt. 2020 Sep;25(9):
pubmed: 32921005
Ann Transl Med. 2015 Jun;3(10):136
pubmed: 26207229
Ann Lab Med. 2016 Jul;36(4):393-5
pubmed: 27139619
Radiology. 2005 Apr;235(1):168-75
pubmed: 15703312
Eur Respir J. 2015 Jun;45(6):1642-52
pubmed: 25573405
Lancet Infect Dis. 2020 Apr;20(4):398-400
pubmed: 32113510
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14
pubmed: 18490652
Adv Virus Res. 2011;81:85-164
pubmed: 22094080
Int J Infect Dis. 2020 Oct;99:397-402
pubmed: 32800855
J Immunol. 2007 Aug 1;179(3):1855-63
pubmed: 17641052
Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-6
pubmed: 24083868
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
J Virol. 2007 Jan;81(2):813-21
pubmed: 17079315
PLoS Negl Trop Dis. 2020 Nov 4;14(11):e0008855
pubmed: 33147214
JAMA Neurol. 2020 Nov 1;77(11):1440-1445
pubmed: 32609336
Stem Cells Int. 2019 Feb 26;2019:5126156
pubmed: 30936922
Trends Microbiol. 2016 Jun;24(6):490-502
pubmed: 27012512
Front Pharmacol. 2016 Aug 03;7:231
pubmed: 27536241
Nat Rev Microbiol. 2006 Feb;4(2):121-32
pubmed: 16415928
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
Anal Cell Pathol (Amst). 2020 Nov 20;2020:1939768
pubmed: 33274176
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
Front Psychiatry. 2020 Nov 16;11:582345
pubmed: 33304284
Front Microbiol. 2020 Sep 30;11:580137
pubmed: 33101254
Front Med. 2017 Dec;11(4):462-470
pubmed: 29159596
Ecancermedicalscience. 2020 Mar 27;14:1022
pubmed: 32256705
Mol Biol Rep. 2020 Dec;47(12):9939-9949
pubmed: 33185828
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975
pubmed: 32350134
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Cochrane Database Syst Rev. 2016 Mar 07;3:CD010406
pubmed: 26950335
Cell Stem Cell. 2015 Jul 2;17(1):11-22
pubmed: 26140604
J Travel Med. 2020 Mar 13;27(2):
pubmed: 32052846
Int J Mol Sci. 2020 Jan 22;21(3):
pubmed: 31979113
Diagn Microbiol Infect Dis. 2018 Jul;91(3):245-247
pubmed: 29550057
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Stem Cell Investig. 2017 Sep 21;4:78
pubmed: 29057250
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518
Ann Intern Med. 2020 Jun 2;172(11):726-734
pubmed: 32282894
Front Mol Biosci. 2020 Sep 30;7:588618
pubmed: 33195436
J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105379
pubmed: 33254369
Cryobiology. 2015 Oct;71(2):181-97
pubmed: 26186998
Stem Cell Res Ther. 2015 Nov 11;6:212
pubmed: 26560482
Viruses. 2019 Mar 19;11(3):
pubmed: 30893947
Br J Pharmacol. 2020 Jul;177(14):3147-3161
pubmed: 32368792
Lancet. 2020 Feb 15;395(10223):473-475
pubmed: 32043983
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Mol Biol Rep. 2020 Nov;47(11):9033-9041
pubmed: 33025503
J Pharmacol Sci. 2019 May;140(1):94-101
pubmed: 31105025
BMJ. 2020 Jul 1;370:m2516
pubmed: 32611558
Trends Pharmacol Sci. 2020 Aug;41(8):513-517
pubmed: 32553545
Rev Med Virol. 2012 Jan;22(1):2-17
pubmed: 21905149
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
Biofactors. 2017 Sep 10;43(5):633-644
pubmed: 28718997
Aging (Albany NY). 2020 Apr 22;12(8):6536-6542
pubmed: 32320384
Biomed Pharmacother. 2020 Jul;127:110195
pubmed: 32361161
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
Inflamm Regen. 2020 Oct 1;40:37
pubmed: 33014208
Mol Med Rep. 2017 Nov;16(5):7432-7438
pubmed: 28944831
Bone Marrow Transplant. 2019 Aug;54(Suppl 2):789-792
pubmed: 31431712
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
EBioMedicine. 2020 May;55:102768
pubmed: 32344202
Cytometry A. 2020 Dec 6;:
pubmed: 33280254
Biomed Pharmacother. 2020 Nov;131:110678
pubmed: 32861070
Clin Infect Dis. 2021 Dec 6;73(11):e4058-e4063
pubmed: 33252665
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
Stem Cells Transl Med. 2017 Dec;6(12):2173-2185
pubmed: 29076267
Blood Transfus. 2016 Mar;14(2):152-7
pubmed: 26674811
Infect Dis Poverty. 2020 Apr 28;9(1):45
pubmed: 32345362
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Front Immunol. 2019 Mar 27;10:594
pubmed: 30972078
J Thorac Oncol. 2020 May;15(5):700-704
pubmed: 32114094
Sci Transl Med. 2020 Jun 3;12(546):
pubmed: 32493791
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Methods Mol Biol. 2015;1282:1-23
pubmed: 25720466
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Immunol Cell Biol. 2018 Apr;96(4):347-357
pubmed: 29377354
J Pathol. 2004 Feb;202(2):157-63
pubmed: 14743497
ACS Nano. 2020 Apr 28;14(4):3822-3835
pubmed: 32223179
Sci Total Environ. 2020 Sep 10;734:139278
pubmed: 32434058
Stem Cells Int. 2019 May 2;2019:4236973
pubmed: 31191672
Front Immunol. 2019 Jun 04;10:1191
pubmed: 31214172
Sci Rep. 2021 Aug 9;11(1):16144
pubmed: 34373540
Cureus. 2020 Mar 26;12(3):e7423
pubmed: 32337143
Stroke. 2011 May;42(5):1420-8
pubmed: 21474801
Am J Respir Crit Care Med. 2018 Mar 15;197(6):757-767
pubmed: 29161116
Int Forum Allergy Rhinol. 2020 Jul;10(7):821-831
pubmed: 32329222
RNA. 2020 Jul;26(7):771-783
pubmed: 32358057
Am J Pathol. 2016 Jan;186(1):78-86
pubmed: 26597880
JAMA Otolaryngol Head Neck Surg. 2020 Jul 1;146(7):674-675
pubmed: 32267483
Pain Physician. 2020 Mar;23(2):E71-E83
pubmed: 32214286
Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2536-41
pubmed: 14983044
Regen Med. 2010 Jan;5(1):121-43
pubmed: 20017699
Infection. 2021 Feb;49(1):15-28
pubmed: 32860214
Clin Microbiol Infect. 2020 Jun;26(6):729-734
pubmed: 32234451
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Front Neurol. 2020 Nov 05;11:574004
pubmed: 33224088
Immunity. 2020 Apr 14;52(4):583-589
pubmed: 32259480
Ann Intern Med. 2021 Jan;174(1):69-79
pubmed: 32941052