Lung Extracellular Matrix as a Platform for Lung Organ Bioengineering: Design and Development of Tissue Engineered Lung.
Decellularization
Lung matrices
Lung stem cells
Recellularization
Scaffold
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
Since lung tissue is not able to be reconstructed after substantial injury, lung transplantation often is the only alternative for treatment. Antibiotic-resistant organisms that remain in donor lungs causing infection in the immunosuppressed recipient are among the complications following transplantation. Development of strategies for whole lung regeneration is a pleasing choice particularly in patients with end-stage lung diseases. Reconstruction of lung tissue in vitro for transplantation received increased attention which could deal with the shortage of donor organs. Recent advancements in the field of tissue engineering and regenerative medicine have paved the road for beneficial alternative therapies. Our group has extensive experience with regard to the structure of the lung tissue, which makes us to our decision to continue with the preparation of lung, with the aim of developing a new ECM scaffold. Herein, we aim to review the state-of-art and the tissue engineering and regenerative medicine technology highlighting the major achievements toward the production of a bioengineered lung obtained decellularization and recellularization techniques. We have strong hopes that recent developments in the engineering of lung will lead to similar breakthroughs in the engineering of distal lung components in the future.
Identifiants
pubmed: 34582012
doi: 10.1007/978-3-030-82735-9_4
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-46Informations de copyright
© 2021. Springer Nature Switzerland AG.
Références
Ali NN, Edgar AJ, Samadikuchaksaraei A, Timson CM, Romanska HM, Polak JM et al (2002) Derivation of type II alveolar epithelial cells from murine embryonic stem cells. Tissue Eng 8(4):541–550
pubmed: 12201994
doi: 10.1089/107632702760240463
pmcid: 12201994
Azargoon A, Negahdari B (2018) Lung regeneration using amniotic fluid mesenchymal stem cells. Artif Cells, Nanomed, Biotechnol 46(3):447–451
doi: 10.1080/21691401.2017.1337023
Badylak SF, Gilbert TW (eds) (2008) Immune response to biologic scaffold materials. Seminars in immunology. Elsevier
Badylak SF, Taylor D, Uygun K (2011) Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng 13:27–53
pubmed: 21417722
doi: 10.1146/annurev-bioeng-071910-124743
Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR et al (2013) Type 2 alveolar cells are stem cells in adult lung. J Clin Investig 123(7):3025–3036
pubmed: 23921127
pmcid: 3696553
doi: 10.1172/JCI68782
Booth AJ, Hadley R, Cornett AM, Dreffs AA, Matthes SA, Tsui JL et al (2012) Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med 186(9):866–876
pubmed: 22936357
pmcid: 3530219
doi: 10.1164/rccm.201204-0754OC
Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF (2009) Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. Biomaterials 30(8):1482–1491
pubmed: 19121538
pmcid: 2805023
doi: 10.1016/j.biomaterials.2008.11.040
Burgstaller G, Oehrle B, Gerckens M, White ES, Schiller HB, Eickelberg O (2017) The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease. Eur Respir J 50(1):1601805
pubmed: 28679607
doi: 10.1183/13993003.01805-2016
pmcid: 28679607
Calle EA, Leiby KL, Raredon MB, Niklason LE (2017) Lung regeneration: steps toward clinical implementation and use. Curr Opin Anaesthesiol 30(1):23
pubmed: 27922848
pmcid: 5283945
doi: 10.1097/ACO.0000000000000425
Chang YS, Oh W, Choi SJ, Sung DK, Kim SY, Choi EY et al (2009) Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant 18(8):869–886
pubmed: 19500472
doi: 10.3727/096368909X471189
pmcid: 19500472
Coraux C, Nawrocki-Raby B, Hinnrasky J, Kileztky C, Gaillard D, Dani C et al (2005) Embryonic stem cells generate airway epithelial tissue. Am J Respir Cell Mol Biol 32(2):87–92
pubmed: 15576671
doi: 10.1165/rcmb.2004-0079RC
pmcid: 15576671
Cortiella J, Nichols JE, Kojima K, Bonassar LJ, Dargon P, Roy AK et al (2006) Tissue-engineered lung: an in vivo and in vitro comparison of polyglycolic acid and pluronic F-127 hydrogel/somatic lung progenitor cell constructs to support tissue growth. Tissue Eng 12(5):1213–1225
pubmed: 16771635
doi: 10.1089/ten.2006.12.1213
pmcid: 16771635
Crapo PM, Gilbert TW, Badylak SF (2011) An overview of tissue and whole organ decellularization processes. Biomaterials 32(12):3233–3243
pubmed: 21296410
pmcid: 3084613
doi: 10.1016/j.biomaterials.2011.01.057
Daly AB, Wallis JM, Borg ZD, Bonvillain RW, Deng B, Ballif BA et al (2012) Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells. Tissue Eng Part A 18(1–2):1–16
pubmed: 21756220
doi: 10.1089/ten.tea.2011.0301
pmcid: 21756220
De Santis MM, Bölükbas DA, Lindstedt S, Wagner DE (2018) How to build a lung: latest advances and emerging themes in lung bioengineering. Eur Respir J 52(1)
Doryab A, Heydarian M, Amoabediny G, Sadroddiny E, Mahfouzi S (2017) Recellularization on acellular lung tissue scaffold using perfusion-based bioreactor: an online monitoring strategy. J Med Biol Eng 37(1):53–62
doi: 10.1007/s40846-016-0205-1
Douglas WH, Moorman GW, Teel RW (1976) The formation of histotypic structures from monodisperse fetal rat lung cells cultured on a three-dimensional substrate. Vitro 12(5):373–381
doi: 10.1007/BF02796315
Fischer SN, Johnson JK, Baran CP, Newland CA, Marsh CB, Lannutti JJ (2011) Organ-derived coatings on electrospun nanofibers as ex vivo microenvironments. Biomaterials 32(2):538–546
pubmed: 20875916
doi: 10.1016/j.biomaterials.2010.08.104
pmcid: 20875916
Garcia O, Carraro G, Navarro S, Bertoncello I, McQualter J, Driscoll B et al (2012) Cell-based therapies for lung disease. Br Med Bull 101(1):147–161
pubmed: 22279079
pmcid: 3695661
doi: 10.1093/bmb/ldr051
Ghaedi M, Calle EA, Mendez JJ, Gard AL, Balestrini J, Booth A et al (2013) Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix. J Clin Investig 123(11):4950–4962
pubmed: 24135142
pmcid: 3809786
doi: 10.1172/JCI68793
Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A et al (2018) Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix. J Tissue Eng Regen Med 12(3):e1623–e1635
pubmed: 29024475
doi: 10.1002/term.2589
pmcid: 29024475
Gilpin SE, Ren X, Okamoto T, Guyette JP, Mou H, Rajagopal J et al (2014) Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg 98(5):1721–1729
pubmed: 25149047
pmcid: 4252658
doi: 10.1016/j.athoracsur.2014.05.080
Gilpin SE, Charest JM, Ren X, Ott HC (2016) Bioengineering lungs for transplantation. Thorac Cardiovasc Surg 26(2):163–171
Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T et al (2014) Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol-Lung Cell Mol Physiol 306(11):L975–L985
pubmed: 24682451
pmcid: 4042188
doi: 10.1152/ajplung.00242.2013
Gotts JE, Matthay MA (2012) Mesenchymal stem cells and the stem cell niche: a new chapter. Am J Physiol-Lung Cell Mol Physiol 302(11):L1147–L1149
pubmed: 22505672
doi: 10.1152/ajplung.00122.2012
pmcid: 22505672
Hoganson DM, Pryor HI, Vacanti JP (2008) Tissue engineering and organ structure: a vascularized approach to liver and lung. Pediatr Res 63(5):520–526
pubmed: 18427297
doi: 10.1203/01.pdr.0000305879.38476.0c
pmcid: 18427297
Hoganson DM, Pryor HI II, Bassett EK, Spool ID, Vacanti JP (2011) Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform. Lab Chip 11(4):700–707
pubmed: 21152606
doi: 10.1039/C0LC00158A
pmcid: 21152606
Huang SX, Islam MN, O’neill J, Hu Z, Yang Y-G, Chen Y-W et al (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 32(1):84
Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR et al (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418(6893):41–49
pubmed: 12077603
doi: 10.1038/nature00870
pmcid: 12077603
Kajbafzadeh A-M, Payabvash S, Salmasi AH, Monajemzadeh M, Tavangar SM (2006) Smooth muscle cell apoptosis and defective neural development in congenital ureteropelvic junction obstruction. J Urol 176(2):718–723
pubmed: 16813927
doi: 10.1016/j.juro.2006.03.041
pmcid: 16813927
Kajbafzadeh A, Sabetkish N, Sabetkish S, Tavangar S, Beigi RH, Talebi M et al (2015a) Lung tissue engineering and preservation of alveolar microstructure using a novel casting method. Biotech Histochem 90(2):111–123
pubmed: 25268847
doi: 10.3109/10520295.2014.957724
Kajbafzadeh AM, Khorramirouz R, Akbarzadeh A, Sabetkish S, Sabetkish N, Saadat P et al (2015b) A novel technique for simultaneous whole-body and multi-organ decellularization: umbilical artery catheterization as a perfusion-based method in a sheep foetus model. Int J Exp Pathol 96(2):116–132
pubmed: 26031202
pmcid: 4459805
doi: 10.1111/iep.12124
Khorramirouz R, Sabetkish S, Akbarzadeh A, Muhammadnejad A, Heidari R, Kajbafzadeh A-M (2014) Effect of three decellularisation protocols on the mechanical behaviour and structural properties of sheep aortic valve conduits. Adv Med Sci 59(2):299–307
pubmed: 25260036
doi: 10.1016/j.advms.2014.08.004
pmcid: 25260036
Kreuter M, Witt S, Polke M, Waelscher J, Schwarzkopf L (2018) Financial burden of interstitial lung disease-a claims data based study. C41. Health services research in pulmonary disease. American Thoracic Society. p A4927-A
Kuttan R, Spall R, Duhamel R, Sipes I, Meezan E, Brendel K (1981) Preparation and composition of alveolar extracellular matrix and incorporated basement membrane. Lung 159(1):333–345
pubmed: 7300440
doi: 10.1007/BF02713933
pmcid: 7300440
Macchiarini P, Jungebluth P, Go T, Asnaghi MA, Rees LE, Cogan TA et al (2008) Clinical transplantation of a tissue-engineered airway. Lancet 372(9655):2023–2030
pubmed: 19022496
doi: 10.1016/S0140-6736(08)61598-6
pmcid: 19022496
Majka SM, Beutz MA, Hagen M, Izzo AA, Voelkel N, Helm KM (2005) Identification of novel resident pulmonary stem cells: form and function of the lung side population. Stem Cells 23(8):1073–1081
pubmed: 15987674
doi: 10.1634/stemcells.2005-0039
pmcid: 15987674
Mandrycky C, Phong K, Zheng Y (2017) Tissue engineering toward organ-specific regeneration and disease modeling. MRS Commun 7(3):332–347
pubmed: 29750131
pmcid: 5939579
doi: 10.1557/mrc.2017.58
McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH et al (2014) Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol-Lung Cell Mol Physiol 306(9):L809–L815
pubmed: 24532289
pmcid: 4010648
doi: 10.1152/ajplung.00358.2013
Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE (2014) Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds. Tissue Eng Part A 20(11–12):1735–1746
pubmed: 24393055
pmcid: 4029048
doi: 10.1089/ten.tea.2013.0647
Mondrinos MJ, Koutzaki S, Jiwanmall E, Li M, Dechadarevian J-P, Lelkes PI et al (2006) Engineering three-dimensional pulmonary tissue constructs. Tissue Eng 12(4):717–728
pubmed: 16674286
doi: 10.1089/ten.2006.12.717
pmcid: 16674286
Neuman RE, Logan MA (1950) The determination of hydroxyproline. J Biol Chem 184(1):299–306
pubmed: 15421999
doi: 10.1016/S0021-9258(19)51149-8
pmcid: 15421999
Nichols JE, Niles J, Riddle M, Vargas G, Schilagard T, Ma L et al (2013) Production and assessment of decellularized pig and human lung scaffolds. Tissue Eng Part A 19(17–18):2045–2062
pubmed: 23638920
pmcid: 3725800
doi: 10.1089/ten.tea.2012.0250
O’Neill JD, Anfang R, Anandappa A, Costa J, Javidfar J, Wobma HM et al (2013) Decellularization of human and porcine lung tissues for pulmonary tissue engineering. Ann Thorac Surg 96(3):1046–1056
pubmed: 23870827
pmcid: 4033908
doi: 10.1016/j.athoracsur.2013.04.022
Orlando G, Farney AC, Iskandar SS, Mirmalek-Sani S-H, Sullivan DC, Moran E et al (2012) Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations. Ann Surg 256(2):363–370
pubmed: 22691371
doi: 10.1097/SLA.0b013e31825a02ab
pmcid: 22691371
Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L et al (2010) Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 16(8):927
pubmed: 20628374
doi: 10.1038/nm.2193
pmcid: 20628374
Panoskaltsis-Mortari A (2015) Bioreactor development for lung tissue engineering. Current Transplant Rep 2(1):90–97
doi: 10.1007/s40472-014-0048-z
Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB et al (2010) Tissue-engineered lungs for in vivo implantation. Science 329(5991):538–541
pubmed: 20576850
pmcid: 3640463
doi: 10.1126/science.1189345
Raredon MSB, Ghaedi M, Calle EA, Niklason LE (2015) A rotating bioreactor for scalable culture and differentiation of respiratory epithelium. Cell Med 7(3):109–121
pubmed: 26858899
doi: 10.3727/215517914X681794
pmcid: 26858899
Ren X, Moser PT, Gilpin SE, Okamoto T, Wu T, Tapias LF et al (2015) Engineering pulmonary vasculature in decellularized rat and human lungs. Nat Biotechnol 33(10):1097
pubmed: 26368048
doi: 10.1038/nbt.3354
pmcid: 26368048
Rippon HJ, Polak JM, Qin M, Bishop AE (2006) Derivation of distal lung epithelial progenitors from murine embryonic stem cells using a novel three-step differentiation protocol. Stem Cells 24(5):1389–1398
pubmed: 16456134
doi: 10.1634/stemcells.2005-0465
pmcid: 16456134
Rosen C, Shezen E, Aronovich A, Klionsky YZ, Yaakov Y, Assayag M et al (2015) Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice. Nat Med 21(8):869
pubmed: 26168294
doi: 10.1038/nm.3889
pmcid: 26168294
Samadikuchaksaraei A, Cohen S, Isaac K, Rippon HJ, Polak JM, Bielby RC et al (2006) Derivation of distal airway epithelium from human embryonic stem cells. Tissue Eng 12(4):867–875
pubmed: 16674299
doi: 10.1089/ten.2006.12.867
pmcid: 16674299
Sato M, Okada Y, Oto T, Minami M, Shiraishi T, Nagayasu T et al (2014) Registry of the Japanese society of lung and heart-lung transplantation: official Japanese lung transplantation report, 2014. Gen Thorac Cardiovasc Surg 62(10):594–601
pubmed: 24842125
doi: 10.1007/s11748-014-0418-6
pmcid: 24842125
Scarritt ME, Pashos NC, Bunnell BA (2015) A review of cellularization strategies for tissue engineering of whole organs. Front Bioeng Biotechnol 3:43
pubmed: 25870857
pmcid: 4378188
doi: 10.3389/fbioe.2015.00043
Shannon JM, Hyatt BA (2004) Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 66:625–645
pubmed: 14977416
doi: 10.1146/annurev.physiol.66.032102.135749
pmcid: 14977416
Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B et al (2015) Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Rep 4(3):419–430
doi: 10.1016/j.stemcr.2015.01.004
Sokocevic D, Bonenfant NR, Wagner DE, Borg ZD, Lathrop MJ, Lam YW et al (2013) The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs. Biomaterials 34(13):3256–3269
pubmed: 23384794
pmcid: 4215729
doi: 10.1016/j.biomaterials.2013.01.028
Sueblinvong V, Loi R, Eisenhauer PL, Bernstein IM, Suratt BT, Spees JL et al (2008) Derivation of lung epithelium from human cord blood–derived mesenchymal stem cells. Am J Respir Crit Care Med 177(7):701–711
pubmed: 18063840
doi: 10.1164/rccm.200706-859OC
pmcid: 18063840
Sullivan DC, Mirmalek-Sani S-H, Deegan DB, Baptista PM, Aboushwareb T, Atala A et al (2012) Decellularization methods of porcine kidneys for whole organ engineering using a high-throughput system. Biomaterials 33(31):7756–7764
pubmed: 22841923
doi: 10.1016/j.biomaterials.2012.07.023
pmcid: 22841923
Takahashi K, Chen F, Ikeda T, Doi H, Nakamura H, Yanagi S et al (2013) Single-lobe lung transplantation for rapidly deteriorating pulmonary venoocclusive disease. Ann Thorac Surg 95(2):689–691
pubmed: 23336879
doi: 10.1016/j.athoracsur.2012.06.031
pmcid: 23336879
Tebyanian H, Karami A, Nourani MR, Motavallian E, Barkhordari A, Yazdanian M et al (2019) Lung tissue engineering: an update. J Cell Physiol 234(11):19256–19270
pubmed: 30972749
doi: 10.1002/jcp.28558
pmcid: 30972749
Tudorache I, Cebotari S, Sturz G, Kirsch L, Hurschler C, Hilfiker A et al. (2007) Tissue engineering of heart valves: biomechanical and morphological properties of decellularized heart valves. J Heart Valve Dis 16(5):567–73. discussion 74
Vranken BV, Romanska H, Polak J, Rippon H, Shannon J, Bishop A (2005) Coculture of embryonic stem cells with pulmonary mesenchyme: a microenvironment that promotes differentiation of pulmonary epithelium. Tissue Eng 11(7–8):1177–1187
pubmed: 16144454
doi: 10.1089/ten.2005.11.1177
pmcid: 16144454
Wagner DE, Bonvillain RW, Jensen T, Girard ED, Bunnell BA, Finck CM et al (2013) Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds. Respirology 18(6):895–911
pubmed: 23614471
doi: 10.1111/resp.12102
pmcid: 23614471
Wagner DE, Bonenfant NR, Parsons CS, Sokocevic D, Brooks EM, Borg ZD et al (2014a) Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 35(10):3281–3297
pubmed: 24461327
pmcid: 4215725
doi: 10.1016/j.biomaterials.2013.12.103
Wagner DE, Bonenfant NR, Sokocevic D, DeSarno MJ, Borg ZD, Parsons CS et al (2014b) Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration. Biomaterials 35(9):2664–2679
pubmed: 24411675
pmcid: 4215726
doi: 10.1016/j.biomaterials.2013.11.078
Wallis JM, Borg ZD, Daly AB, Deng B, Ballif BA, Allen GB et al (2012) Comparative assessment of detergent-based protocols for mouse lung de-cellularization and re-cellularization. Tissue Eng Part C Methods 18(6):420–432
pubmed: 22165818
pmcid: 3358122
doi: 10.1089/ten.tec.2011.0567
Weibel ER (2017) Lung morphometry: the link between structure and function. Cell Tissue Res 367(3):413–426
pubmed: 27981379
doi: 10.1007/s00441-016-2541-4
pmcid: 27981379
Wong AP, Keating A, Lu W-Y, Duchesneau P, Wang X, Sacher A et al (2009) Identification of a bone marrow–derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Investig 119(2):336–348
pubmed: 19164856
pmcid: 2631300
Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan L-J et al (2012) Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 30(9):876
pubmed: 22922672
pmcid: 3994104
doi: 10.1038/nbt.2328
Zhou H, Kitano K, Ren X, Rajab TK, Wu M, Gilpin SE et al (2018) Bioengineering human lung grafts on porcine matrix. Ann Surg 267(3):590–598
pubmed: 28085694
doi: 10.1097/SLA.0000000000002129
pmcid: 28085694