Real-Time Observation of "Soft" Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate.

Bismuth Organometallic Compounds Salicylates

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
13 10 2021
Historique:
pubmed: 29 9 2021
medline: 19 2 2022
entrez: 28 9 2021
Statut: ppublish

Résumé

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi

Identifiants

DOI: 10.1021/jacs.1c07186 PMID: 34582201
pubmed: 34582201
doi: 10.1021/jacs.1c07186
doi:

Substances chimiques

Organometallic Compounds 0
Salicylates 0
bismuth subsalicylate 62TEY51RR1
Bismuth U015TT5I8H

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16332-16336

Auteurs

Daniel Szczerba (D)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.

Davin Tan (D)

Department of Chemistry, McGill University, Montréal, Québec H3A 0B8, Canada.

Jean-Louis Do (JL)

Department of Chemistry, McGill University, Montréal, Québec H3A 0B8, Canada.

Hatem M Titi (HM)

Department of Chemistry, McGill University, Montréal, Québec H3A 0B8, Canada.
ORCID: 0000-0002-0654-1292

Siham Mouhtadi (S)

Université Franche-Comté, Insitut UTINAM-Équipe MSF, and Université Bourgogne Franche-Comté, 25030 Besançon, France.

Denis Chaumont (D)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.

María Del Carmen Marco de Lucas (M)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.

Nicolas Geoffroy (N)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.

Michel Meyer (M)

Insitut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche Comté, 9 Avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.
ORCID: 0000-0003-2295-7826

Yoann Rousselin (Y)

Insitut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche Comté, 9 Avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.

Jessica M Hudspeth (JM)

European Synchrotron Radiation Facility, BP 156, 38042 Grenoble, France.

Valérie Schwanen (V)

University of Liège, Allée du six août, 11-4000 Liège, Belgium.

Petra Spoerk-Erdely (P)

Department of Materials Science, Montanuniversität Leoben, Franz Josef-Strasse 18, 8700 Leoben, Austria.

Ann-Christin Dippel (AC)

Deutsches Elektronen-Synchrotron DESY, Notkestraße 95, 22603 Hamburg, Germany.

Oleh Ivashko (O)

Deutsches Elektronen-Synchrotron DESY, Notkestraße 95, 22603 Hamburg, Germany.

Olof Gutowski (O)

Deutsches Elektronen-Synchrotron DESY, Notkestraße 95, 22603 Hamburg, Germany.

Philipp Glaevecke (P)

Deutsches Elektronen-Synchrotron DESY, Notkestraße 95, 22603 Hamburg, Germany.

Vasilii Bazhenov (V)

European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.

Mihails Arhangelskis (M)

Faculty of Chemistry, University of Warsaw, 1 Pasteura Street, 02-093 Warsaw, Poland.

Ivan Halasz (I)

Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
ORCID: 0000-0002-5248-4217

Tomislav Friščić (T)

Department of Chemistry, McGill University, Montréal, Québec H3A 0B8, Canada.
ORCID: 0000-0002-3921-7915

Simon A J Kimber (SAJ)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, F-21078 Dijon Cedex, France.
ORCID: 0000-0003-0489-1851

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Bismuth › Real-Time Observation of "Soft" Magic-Size...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Real-Time Observation of "Soft" Magic-Size...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Salicylates › Real-Time Observation of "Soft" Magic-Size...