Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
02
2021
accepted:
29
07
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
17
11
2021
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ10 levels and oxidative stress in RA patients. Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ10 was determined by HPLC method; TBARS were detected spectrophotometrically. Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ10 levels were observed in RA patients compared with normal controls. The observed decrease in platelet CoQ10 levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ10 levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases.
Identifiants
pubmed: 34582480
doi: 10.1371/journal.pone.0256135
pii: PONE-D-21-06071
pmc: PMC8478238
doi:
Substances chimiques
Biomarkers
0
Ubiquinone
1339-63-5
coenzyme Q10
EJ27X76M46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0256135Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Science. 2001 Apr 20;292(5516):504-7
pubmed: 11283355
Bratisl Lek Listy. 2019;120(9):630-635
pubmed: 31475544
Bratisl Lek Listy. 2020;121(10):693-699
pubmed: 32955899
JAMA. 2018 Oct 2;320(13):1360-1372
pubmed: 30285183
Mitochondrion. 2013 Nov;13(6):795-800
pubmed: 23688905
Best Pract Res Clin Rheumatol. 2017 Feb;31(1):3-18
pubmed: 29221595
Prim Care. 2018 Jun;45(2):237-255
pubmed: 29759122
J Rheumatol. 1997 Aug;24(8):1477-85
pubmed: 9263138
Arch Med Res. 2015 Oct;46(7):527-33
pubmed: 26342738
Arthritis Rheum. 2003 Mar;48(3):700-8
pubmed: 12632423
J Cell Biol. 2016 Feb 29;212(5):531-44
pubmed: 26903540
Clin Chim Acta. 2004 Apr;342(1-2):219-26
pubmed: 15026284
Anal Biochem. 1986 Aug 15;157(1):106-16
pubmed: 3766953
BMC Genomics. 2009 Aug 21;10:388
pubmed: 19698090
Rheumatol Int. 2002 Mar;21(5):200-4
pubmed: 11958437
Diagnostics (Basel). 2020 Mar 23;10(3):
pubmed: 32210203
Transfus Med. 2011 Jun;21(3):166-74
pubmed: 21208306
Cent Eur J Immunol. 2017;42(3):259-268
pubmed: 29204090
J Inherit Metab Dis. 2017 Sep;40(5):673-683
pubmed: 28451918
Biochem Soc Trans. 2017 Dec 15;45(6):1213-1223
pubmed: 29054925
Transl Oncol. 2021 Jan;14(1):100890
pubmed: 33059122
Oxid Med Cell Longev. 2014;2014:798957
pubmed: 24707344
Front Cardiovasc Med. 2019 Oct 29;6:153
pubmed: 31737646
Lancet. 2016 Oct 22;388(10055):2023-2038
pubmed: 27156434
Blood. 2019 Aug 29;134(9):727-740
pubmed: 31311815
Physiol Res. 1998;47(6):399-404
pubmed: 10453746
Front Genet. 2020 Jan 17;10:1335
pubmed: 32010192
Saudi Med J. 2016 Apr;37(4):354-60
pubmed: 27052277
Sci Rep. 2019 Dec 10;9(1):18699
pubmed: 31822748
Anal Biochem. 2002 Jun 1;305(1):49-54
pubmed: 12018945
Cells. 2020 Apr 03;9(4):
pubmed: 32260219
PLoS One. 2009 Jul 16;4(7):e6242
pubmed: 19606218
Biochem J. 2000 Jun 1;348 Pt 2:425-32
pubmed: 10816438
Mol Cell Biochem. 2014 Jun;391(1-2):225-32
pubmed: 24610042
Clin Biochem. 2019 Oct;72:71-80
pubmed: 30954436
Lipids. 1989 Feb;24(2):125-31
pubmed: 2547130
PLoS One. 2019 Nov 8;14(11):e0224632
pubmed: 31703070
Mitochondrion. 2013 Jan;13(1):7-14
pubmed: 23164798
ScientificWorldJournal. 2014 Mar 03;2014:781857
pubmed: 24729754
PLoS One. 2016 Apr 04;11(4):e0152925
pubmed: 27043143
Blood Adv. 2018 Aug 14;2(15):2029-2038
pubmed: 30108111
Arthritis Res Ther. 2018 May 29;20(1):95
pubmed: 29843785
Nat Rev Rheumatol. 2016 Jul;12(7):385-97
pubmed: 27225300
Rheumatology (Oxford). 2012 Oct;51(10):1796-803
pubmed: 22814531
Gen Physiol Biophys. 2019 Jul;38(4):325-334
pubmed: 31241044
Oxid Med Cell Longev. 2019 Dec 14;2019:7536805
pubmed: 31934269
Rev Invest Clin. 2015 Jan-Feb;67(1):46-53
pubmed: 25857584
Methods Mol Biol. 2012;810:25-58
pubmed: 22057559