Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
Aged
Brain
/ blood supply
Cerebrovascular Circulation
Cognitive Dysfunction
/ diagnostic imaging
Female
Healthy Volunteers
Humans
Magnetic Resonance Imaging
Male
Mental Status and Dementia Tests
Middle Aged
Neuropsychological Tests
Pulse Wave Analysis
Sex Characteristics
Spin Labels
Vascular Stiffness
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
01
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
19
11
2021
Statut:
epublish
Résumé
It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship between AS and CVR is more complex, where some studies show decreased CVR with increased AS, and others demonstrate preserved CVR despite higher AS. Here, we investigated the possible role of sex on these hemodynamic relationships. Acquisitions were completed in 48 older adults. Pseudo-continuous arterial spin labeling (pCASL) data were collected during a hypercapnia challenge. Aortic pulse wave velocity (PWV) data was acquired using cine phase contrast velocity series. Cognitive function was assessed with a comprehensive neuropsychological battery, and a composite score for EF was calculated using four cognitive tests from the neuropsychological battery. A moderation model test revealed that sex moderated the relationship between PWV and CVR and PWV and EF, but not between CVR and EF. Together, our results indicate that the relationships between central stiffness, cerebral hemodynamics and cognition are in part mediated by sex.
Identifiants
pubmed: 34582484
doi: 10.1371/journal.pone.0257815
pii: PONE-D-21-01181
pmc: PMC8478243
doi:
Substances chimiques
Spin Labels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0257815Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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