Compartmentalization of Sphingolipid metabolism: Implications for signaling and therapy.
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
02
08
2021
revised:
13
09
2021
accepted:
23
09
2021
pubmed:
29
9
2021
medline:
1
4
2022
entrez:
28
9
2021
Statut:
ppublish
Résumé
Sphingolipids (SLs) are a family of bioactive lipids implicated in a variety of cellular processes, and whose levels are controlled by an interlinked network of enzymes. While the spatial distribution of SL metabolism throughout the cell has been understood for some time, the implications of this for SL signaling and biological outcomes have only recently begun to be fully explored. In this review, we outline the compartmentalization of SL metabolism and describe advances in tools for investigating and probing compartment-specific SL functions. We also briefly discuss the implications of SL compartmentalization for cell signaling and therapeutic approaches to targeting the SL network.
Identifiants
pubmed: 34582834
pii: S0163-7258(21)00207-2
doi: 10.1016/j.pharmthera.2021.108005
pmc: PMC9619385
mid: NIHMS1843790
pii:
doi:
Substances chimiques
Sphingolipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108005Subventions
Organisme : NCI NIH HHS
ID : R01 CA248014
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA248080
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.
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