Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
Bacteria
/ classification
Butyrates
/ metabolism
Carcinogenesis
/ pathology
Cellular Senescence
/ physiology
Colorectal Neoplasms
/ microbiology
Epithelial Cells
/ microbiology
Feces
/ microbiology
Gastrointestinal Microbiome
Humans
Intestines
/ cytology
Porphyromonas
/ genetics
RNA, Ribosomal, 16S
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
received:
17
10
2020
accepted:
06
09
2021
entrez:
29
9
2021
pubmed:
30
9
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate. Notably, the invasion of these bacteria is observed in the CRC tissues, coinciding with the elevation of butyrate levels and signs of senescence-associated inflammatory phenotypes. Moreover, although the administration of these bacteria into Apc
Identifiants
pubmed: 34584098
doi: 10.1038/s41467-021-25965-x
pii: 10.1038/s41467-021-25965-x
pmc: PMC8479117
doi:
Substances chimiques
Butyrates
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5674Informations de copyright
© 2021. The Author(s).
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