Neuroendocrine neoplasia and bone (Review).
bone
carcinoid
dual-energy X-ray absorptiometry
ectopic Cushing syndrome
fractures
neuroendocrine neoplasia
osteoporosis
pheocromocytoma
serotonin
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
29
06
2021
accepted:
29
07
2021
entrez:
29
9
2021
pubmed:
30
9
2021
medline:
30
9
2021
Statut:
ppublish
Résumé
This is a narrative review focusing on neuroendocrine neoplasia (NEN) and bone status, in terms of metastases and osteoporosis/fractures. One fifth of NEN have skeletal dissemination, this affinity being regulated by intrinsic tumor factors such as the C-X-C chemokine receptor 4 (CXCR4). Bone colonization impairs the patient quality of life, representing a surrogate of reduced survival. Patients with NEN without bone metastases may exhibit low bone mineral density, perhaps carcinoid-related osteoporosis, yet not a standardized cause of osteoporosis. Case-finding strategies to address bone health in NEN with a good prognosis are lacking. Contributors to fractures in NEN subjects may include: menopausal status and advanced age, different drugs, induced hypogonadism, malnutrition, malabsorption (due to intestinal resection, carcinoid syndrome), hypovitaminosis D, impaired glucose profile (due to excessive hormones such as glucagon, somatostatinoma or use of somatostatin analogues), various corticoid regimes, and high risk of fall due to sarcopenia. Pheocromocytoma/paraganglioma involve bone through malignant forms (bone is an elective site) and potential secondary osteoporosis due to excessive hormonal content and increased sympathetic activity which is a key player of bone microarchitecture/quality as reflected by low Trabecular Bone Score. Glucocorticoid osteoporosis is related to NEN-associated ectopic Cushing syndrome. Currently, there are a lack of studies to emphasis that excessive gut-derivate serotonin in NENs with carcinoid syndrome is a specific activator of bone loss thus a contributor to carcinoid-related osteoporosis.
Identifiants
pubmed: 34584564
doi: 10.3892/etm.2021.10653
pii: ETM-0-0-10653
pmc: PMC8422397
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1219Informations de copyright
Copyright © 2020, Spandidos Publications.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Arch Med Res. 2020 Nov;51(8):765-776
pubmed: 32654882
Curr Treat Options Oncol. 2020 Aug 29;21(11):85
pubmed: 32862332
Pol Arch Med Wewn. 2014;124(11):635-6
pubmed: 25234617
Ophthalmic Plast Reconstr Surg. 2019 Nov/Dec;35(6):e131-e134
pubmed: 31593045
Exp Ther Med. 2020 Sep;20(3):2489-2492
pubmed: 32765740
Oncotarget. 2018 Apr 10;9(27):19245-19254
pubmed: 29721198
Ann Diagn Pathol. 2017 Aug;29:11-16
pubmed: 28807335
J Physiol Pharmacol. 2015 Dec;66(6):779-91
pubmed: 26769827
J Med Life. 2015;8 Spec Issue:82-6
pubmed: 26361517
Prz Gastroenterol. 2020;15(3):207-214
pubmed: 33005265
J Clin Med. 2020 Aug 12;9(8):
pubmed: 32806580
BMC Cancer. 2016 Jan 22;16:36
pubmed: 26801624
Bratisl Lek Listy. 2017;118(9):529-534
pubmed: 29061059
Endocr Relat Cancer. 2015 Jun;23(6):R229-47
pubmed: 27207564
Eur J Endocrinol. 2011 Sep;165(3):383-92
pubmed: 21715416
Osteoporos Int. 2017 May;28(5):1507-1529
pubmed: 28175979
Cancer Treat Rev. 2016 Mar;44:26-41
pubmed: 26855376
BMJ Case Rep. 2019 Aug 21;12(8):
pubmed: 31439569
Nutrients. 2020 Apr 08;12(4):
pubmed: 32276412
J Womens Health (Larchmt). 2018 Sep;27(9):1093-1096
pubmed: 29583083
Singapore Med J. 2009 Apr;50(4):e147-50
pubmed: 19421671
J Korean Med Sci. 2020 Nov 30;35(46):e403
pubmed: 33258332
Endocrinol Metab Clin North Am. 2018 Jun;47(2):409-425
pubmed: 29754641
Exp Gerontol. 2020 Jan;129:110778
pubmed: 31705966
World J Gastroenterol. 2019 Mar 14;25(10):1171-1184
pubmed: 30886501
Endocr Connect. 2015 Mar;4(1):9-17
pubmed: 25430999
Arch Pathol Lab Med. 2021 Jun 1;145(6):664-677
pubmed: 32233993
Eur J Cancer. 2019 Nov;121:7-18
pubmed: 31525487
J Endocrinol Invest. 2020 Oct;43(10):1429-1445
pubmed: 32415572
Farm Hosp. 2020 Nov 14;45(1):41-44
pubmed: 33443477
Kaohsiung J Med Sci. 2012 Jun;28(6):341-4
pubmed: 22632891
Int J Cancer. 2016 Dec 15;139(12):2679-2686
pubmed: 27553864
Clin Nucl Med. 2017 Oct;42(10):773-775
pubmed: 28759524
J Gen Intern Med. 2008 Jun;23(6):875-8
pubmed: 18386102
Indian J Surg Oncol. 2020 Sep;11(3):433-437
pubmed: 33013123
Eur J Med Genet. 2020 Apr;63(4):103815
pubmed: 31783133
Int J Geriatr Psychiatry. 2018 Dec;33(12):1688-1708
pubmed: 30247774
Radiol Clin North Am. 2020 Nov;58(6):1147-1159
pubmed: 33040854
Endocrine. 2019 Jun;64(3):690-701
pubmed: 30635793
Melanoma Res. 2018 Dec;28(6):641-644
pubmed: 30124538
Bone. 2018 Nov;116:1-7
pubmed: 29969750
Eur J Endocrinol. 2020 Apr;182(4):R29-R58
pubmed: 31999619
Am J Transl Res. 2020 Jan 15;12(1):118-129
pubmed: 32051741
Physiol Res. 2019 Nov 30;68(Suppl 2):S149-S156
pubmed: 31842578
Front Endocrinol (Lausanne). 2020 Nov 18;11:591501
pubmed: 33312161
Histopathology. 2008 Jan;52(2):119-29
pubmed: 17825057
Front Endocrinol (Lausanne). 2019 Aug 30;10:580
pubmed: 31543864
Prz Menopauzalny. 2017 Jun;16(2):70-73
pubmed: 28721134
Spine J. 2019 Mar;19(3):411-417
pubmed: 30142455
Endocrine. 2018 Mar;59(3):547-554
pubmed: 29305799
J Clin Endocrinol Metab. 2013 Apr;98(4):1492-7
pubmed: 23436918
Clin Nucl Med. 2019 Mar;44(3):257-258
pubmed: 30624276
Curr Osteoporos Rep. 2020 Feb;18(1):38-46
pubmed: 32103393
Virchows Arch. 2018 Mar;472(3):341-349
pubmed: 29134440
Curr Opin Endocrinol Diabetes Obes. 2020 Jun;27(3):146-154
pubmed: 32250975
Biochimie. 2019 Jun;161:56-64
pubmed: 29909048
J Bone Miner Res. 2014 Sep;29(9):1926-8
pubmed: 24956507
Histopathology. 2021 Jan;78(1):162-170
pubmed: 33382490
Hormones (Athens). 2016 Oct;15(4):540-547
pubmed: 28222414
Rom J Morphol Embryol. 2011;52(1):187-92
pubmed: 21424054
Clin Endocrinol (Oxf). 2014 Feb;80(2):246-52
pubmed: 23790044
Pancreas. 2020 Oct;49(9):1123-1130
pubmed: 32991344
World J Nucl Med. 2017 Jan-Mar;16(1):62-67
pubmed: 28217023
Exp Ther Med. 2020 Oct;20(4):3389-3393
pubmed: 32905095
World J Surg Oncol. 2013 Jun 05;11:128
pubmed: 23734899
Exp Ther Med. 2020 Oct;20(4):3383-3388
pubmed: 32905002
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S8
pubmed: 23259759
Eur Radiol. 2018 Sep;28(9):3943-3952
pubmed: 29532242
J Endocrinol Invest. 2019 Oct;42(10):1149-1164
pubmed: 30980341
Cancers (Basel). 2019 Sep 08;11(9):
pubmed: 31500357
Neuroendocrinology. 2021;111(3):207-216
pubmed: 32403104
Bone. 2020 Apr;133:115221
pubmed: 31940499
Semin Oncol. 2018 Aug;45(4):249-258
pubmed: 30348533
Br Med Bull. 2020 May 15;133(1):105-117
pubmed: 32282039
Eur Radiol. 2021 Jun;31(6):4166-4174
pubmed: 33247341
Clin Endocrinol (Oxf). 2019 Nov;91(5):633-638
pubmed: 31348545
Clin Rheumatol. 2021 Feb;40(2):775-782
pubmed: 32666178
Radiol Clin North Am. 2020 Nov;58(6):1161-1171
pubmed: 33040855
Osteoporos Int. 2020 Aug;31(8):1499-1506
pubmed: 32239237
Clin Nucl Med. 2017 Jun;42(6):463-464
pubmed: 28240655
Bone Res. 2013 Sep 25;1(3):260-6
pubmed: 26273507
Br J Neurosurg. 2019 Dec;33(6):620-623
pubmed: 31583907
Sisli Etfal Hastan Tip Bul. 2020 Jun 03;54(2):159-168
pubmed: 32617052
BMC Endocr Disord. 2020 Apr 3;20(1):44
pubmed: 32245472
Cancer Med. 2019 Dec;8(17):7288-7298
pubmed: 31609098
Semin Musculoskelet Radiol. 2014 Apr;18(2):149-65
pubmed: 24715447
Oncol Lett. 2012 May;3(5):1105-1108
pubmed: 22783400
Neuroendocrinology. 2020;110(7-8):688-696
pubmed: 31639796
Curr Oncol Rep. 2017 Oct 28;19(12):83
pubmed: 29081018
Endocrinol Metab Clin North Am. 2018 Jun;47(2):299-311
pubmed: 29754633
J Med Life. 2020 Oct-Dec;13(4):449-453
pubmed: 33456590
Cancer Metastasis Rev. 2013 Jun;32(1-2):189-200
pubmed: 23090259
Curr Opin Endocrinol Diabetes Obes. 2019 Jun;26(3):125-132
pubmed: 30973393
Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):79-89
pubmed: 26246012
Ann Hepatobiliary Pancreat Surg. 2017 Feb;21(1):61-65
pubmed: 28317048
Medicine (Baltimore). 2019 Nov;98(44):e17773
pubmed: 31689842
Sci Rep. 2020 Jan 29;10(1):1456
pubmed: 31996766
Rom J Morphol Embryol. 2013;54(1):201-3
pubmed: 23529331
Br J Cancer. 2019 Feb;120(3):294-300
pubmed: 30636773
Clin Endocrinol (Oxf). 2018 Aug;89(2):148-154
pubmed: 29781519
J Clin Endocrinol Metab. 2012 Jul;97(7):2223-30
pubmed: 22508705
Bone. 2021 Jan;142:115607
pubmed: 32829039
J Ayub Med Coll Abbottabad. 2016 Jul-Sep;28(3):617-619
pubmed: 28712250
BMC Endocr Disord. 2017 Jul 13;17(1):39
pubmed: 28705205
Osteoporos Int. 2020 Nov;31(11):2151-2160
pubmed: 32617610
Oncotarget. 2017 Apr 4;8(14):22534-22549
pubmed: 28186979