Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity.
3-HK
DLBCL
KMO
KYN pathway
NAD+
Journal
Oncology letters
ISSN: 1792-1082
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
21
06
2021
accepted:
03
09
2021
entrez:
29
9
2021
pubmed:
30
9
2021
medline:
30
9
2021
Statut:
ppublish
Résumé
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy that is the most common type of lymphoma in Japan. Previous studies have demonstrated that patients with DLBCL have a poor prognosis due to increased levels of indoleamine 2,3-dioxygnase and kynurenine (KYN). However, the roles of metabolites acting downstream of KYN and associated enzymes are not fully understood. The present study investigated the role of kynurenine 3-monooxygenase (KMO), which catalyzes the conversion of KYN to 3-hydroxykynurenine (3-HK), using serum samples from patients with DLBCL and human DLBCL cell lines with different KMO expression [STR-428 cells with high levels of KMO expression (KMO
Identifiants
pubmed: 34584567
doi: 10.3892/ol.2021.13051
pii: OL-0-0-13051
pmc: PMC8461759
doi:
Types de publication
Journal Article
Langues
eng
Pagination
790Informations de copyright
Copyright: © Morita et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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