Evaluation of the effect of Lepidium meyenii Walpers in infertile patients: A randomized, double-blind, placebo-controlled trial.
clinical trial
hormone levels
infertility
maca
semen parameters
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
01
09
2021
received:
14
01
2021
accepted:
02
09
2021
pubmed:
30
9
2021
medline:
26
11
2021
entrez:
29
9
2021
Statut:
ppublish
Résumé
Male infertility refers to the inability to conceive a natural pregnancy in a fertile female, and approximately 15% of reproductive-aged couples worldwide face this problem. Several plants were used to treat fertility disorders and, among them, Lepidium meyenii, a folk medicament of Andean regions, is still used to enhance vitality and treat sterility in humans and domestic animals. The aim of the study was to evaluate the effects of L. meyenii Walpers on infertile patients by a randomized, double-blind, placebo-controlled trial. Fifty patients suffering from various reproductive-related problems were enrolled for 16 weeks to evaluate the effect of yellow maca on semen quality and serum hormone levels. Treatment with maca improved the percentage of sperm concentration by 40%, whereas the placebo improved by 76% after 8 and 16 weeks of treatment, but the results were statistically non-significant. No statistically significant change in hormone levels was reported by using maca, except a decrease in the level of free testosterone. Results are not sufficient to assess the efficacy of maca on male fertility. Further investigation and trials are required to obtain conclusive results.
Identifiants
pubmed: 34585449
doi: 10.1002/ptr.7287
pmc: PMC9293450
doi:
Substances chimiques
Plant Extracts
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
6359-6368Subventions
Organisme : Česká Zemědělská Univerzita v Praze
Organisme : Charles University
ID : IGA No 20205004
Informations de copyright
© 2021 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.
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