Noninvasive prenatal testing: Advancing through a virtuous circle of science, technology and clinical applications.
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
entrez:
29
9
2021
pubmed:
30
9
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Since the discovery of cell-free fetal DNA in maternal blood in 1997, the interplay of basic scientific observations and technological developments have continued to drive new clinical applications in the field. This commentary discusses a number of examples in this virtuous circle of science, technology and clinical applications. MATERIALS & METHODS: Commentary and literature review. One example of technological developments is the detection technologies for detecting circulating DNA, moving from conventional PCR, to real-time PCR, to massively parallel sequencing. One example of basic scientific understanding is the size and fragmentation patterns of circulating DNA. Beyond creating a global paradigm in prenatal medicine, the development of noninvasive prenatal testing has also impacted other areas such as cancer screening and transplantation monitoring. Finally, the commentary looks forward to what might be in store in the next decade.
Sections du résumé
BACKGROUND
BACKGROUND
Since the discovery of cell-free fetal DNA in maternal blood in 1997, the interplay of basic scientific observations and technological developments have continued to drive new clinical applications in the field.
AIMS
OBJECTIVE
This commentary discusses a number of examples in this virtuous circle of science, technology and clinical applications. MATERIALS & METHODS: Commentary and literature review.
RESULTS
RESULTS
One example of technological developments is the detection technologies for detecting circulating DNA, moving from conventional PCR, to real-time PCR, to massively parallel sequencing. One example of basic scientific understanding is the size and fragmentation patterns of circulating DNA.
DISCUSSION
CONCLUSIONS
Beyond creating a global paradigm in prenatal medicine, the development of noninvasive prenatal testing has also impacted other areas such as cancer screening and transplantation monitoring. Finally, the commentary looks forward to what might be in store in the next decade.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1190-1192Subventions
Organisme : Li Ka Shing Foundation Hong Kong
ID : Endowed Chair
Organisme : Hong Kong Research Grants Council Theme-Based Research Scheme
ID : T12-403/15N
Organisme : Innovation and Technology Commission Hong Kong
ID : InnoHK scheme
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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