The Current Status of Latency Reversing Agents for HIV-1 Remission.

CD4-Positive T-Lymphocytes HIV Infections / drug therapy HIV-1 / physiology Humans Virus Activation Virus Latency
HIV-1 latency combinatory treatments latency reversing agents shock and kill strategy viral reservoirs

Journal

Annual review of virology
ISSN: 2327-0578
Titre abrégé: Annu Rev Virol
Pays: United States
ID NLM: 101625721

Informations de publication

Date de publication:
29 09 2021
Historique:
entrez: 29 9 2021
pubmed: 30 9 2021
medline: 5 3 2022
Statut: ppublish

Résumé

Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected cellular reservoirs. These reservoirs are mainly composed of CD4

Identifiants

DOI: 10.1146/annurev-virology-091919-103029 PMID: 34586875
pubmed: 34586875
doi: 10.1146/annurev-virology-091919-103029
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

491-514

Auteurs

Anthony Rodari (A)

Service of Molecular Virology, Department of Molecular Biology, Université Libre de Bruxelles (ULB), 6041 Gosselies, Belgium; email: Carine.Vanlint@ulb.be.

Gilles Darcis (G)

Infectious Diseases Department, Liège University Hospital, 4000 Liège, Belgium.

Carine M Van Lint (CM)

Service of Molecular Virology, Department of Molecular Biology, Université Libre de Bruxelles (ULB), 6041 Gosselies, Belgium; email: Carine.Vanlint@ulb.be.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › The Current Status of Latency Reversing Agents...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › The Current Status of Latency Reversing Agents...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › The Current Status of Latency Reversing Agents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Current Status of Latency Reversing Agents...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Activation virale › The Current Status of Latency Reversing Agents...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › The Current Status of Latency Reversing Agents...