Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex.
bipolar disorder
creativity
polygenic risk score
prefrontal cortex
voxel-based morphometry
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
revised:
26
08
2021
received:
08
04
2021
accepted:
13
09
2021
pubmed:
30
9
2021
medline:
29
3
2022
entrez:
29
9
2021
Statut:
ppublish
Résumé
It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
Identifiants
pubmed: 34587347
doi: 10.1002/hbm.25667
pmc: PMC8596941
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6028-6037Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Neuroimage. 2020 Aug 1;216:116825
pubmed: 32344064
Hum Brain Mapp. 2017 Jan;38(1):414-430
pubmed: 27647672
J Clin Psychiatry. 2015 Jun;76(6):e809-14
pubmed: 26132690
Biol Psychiatry. 2013 Jan 15;73(2):144-52
pubmed: 22818781
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
J Int Neuropsychol Soc. 2001 Jul;7(5):586-96
pubmed: 11459110
JAMA Psychiatry. 2021 Mar 1;78(3):320-330
pubmed: 33263727
Neuroimage. 2010 Jun;51(2):578-85
pubmed: 20226253
Nat Genet. 2019 May;51(5):793-803
pubmed: 31043756
Sci Rep. 2017 Feb 10;7:42140
pubmed: 28186152
Neuroimage. 2007 Nov 15;38(3):519-28
pubmed: 17884587
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
J Affect Disord. 2011 Dec;135(1-3):292-7
pubmed: 21767880
Gigascience. 2019 Jul 1;8(7):
pubmed: 31307061
Mol Psychiatry. 2017 Oct;22(10):1455-1463
pubmed: 27217146
Am J Hum Genet. 1995 Sep;57(3):690-702
pubmed: 7668299
Psychon Bull Rev. 2004 Dec;11(6):1011-26
pubmed: 15875970
Mol Neuropsychiatry. 2017 Feb;2(4):198-212
pubmed: 28277566
Nat Neurosci. 2015 Jul;18(7):953-5
pubmed: 26053403
Hum Brain Mapp. 2021 Dec 15;42(18):6028-6037
pubmed: 34587347
Hum Brain Mapp. 2015 May;36(5):1808-27
pubmed: 25627674
Lancet. 2009 Jan 17;373(9659):234-9
pubmed: 19150704
Neuroimage. 2015 Apr 15;110:124-35
pubmed: 25659462
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Mar;4(3):243-250
pubmed: 30243642
Am J Hum Genet. 2009 Feb;84(2):210-23
pubmed: 19200528
Neuroimage. 2012 Feb 1;59(3):2899-907
pubmed: 21988892
J Psychiatr Res. 2013 Dec;47(12):1955-66
pubmed: 24070910
J Am Acad Child Adolesc Psychiatry. 2019 Jun;58(6):600-607
pubmed: 30768412
J Affect Disord. 2018 Jul;234:148-155
pubmed: 29529547
Perspect Psychol Sci. 2009 May;4(3):319-24
pubmed: 26158970
Cortex. 2013 Sep;49(8):2106-25
pubmed: 23079491
Front Psychol. 2015 Jul 07;6:912
pubmed: 26217259
Brain Imaging Behav. 2019 Jun;13(3):862-877
pubmed: 29748770
Neuroimage. 2011 Mar 15;55(2):681-7
pubmed: 21111830
J Abnorm Psychol. 1988 Aug;97(3):281-8
pubmed: 3192819
Neuroimage. 2017 May 15;152:258-269
pubmed: 28257930