Blood and immune development in human fetal bone marrow and Down syndrome.
B-Lymphocytes
/ cytology
Bone Marrow
Bone Marrow Cells
/ cytology
Dendritic Cells
/ cytology
Down Syndrome
/ blood
Endothelial Cells
/ pathology
Eosinophils
/ cytology
Erythroid Cells
/ cytology
Fetus
/ cytology
Granulocytes
/ cytology
Hematopoiesis
Humans
Immune System
/ cytology
Immunity
Myeloid Cells
/ cytology
Stromal Cells
/ cytology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
30
07
2020
accepted:
18
08
2021
pubmed:
1
10
2021
medline:
19
11
2021
entrez:
30
9
2021
Statut:
ppublish
Résumé
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11-12 weeks after conception
Identifiants
pubmed: 34588693
doi: 10.1038/s41586-021-03929-x
pii: 10.1038/s41586-021-03929-x
pmc: PMC7612688
mid: EMS144548
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-331Subventions
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 215116
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216632
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206328
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221052
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : MR/R006237/1
Pays : India
Organisme : Medical Research Council
ID : MR/M008975/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S036113/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT107931/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107630
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N005872/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT206194
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107630/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12009/14
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W014556/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203151/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT211276/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216632/Z/19/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S036334/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206328/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107931
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211276
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
Références
O’Byrne, S. et al. Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs. Blood 134, 1059–1071 (2019).
doi: 10.1182/blood.2019001289
Charbord, P., Tavian, M., Humeau, L. & Péault, B. Early ontogeny of the human marrow from long bones: an immunohistochemical study of hematopoiesis and its microenvironment. Blood 87, 4109–4119 (1996).
doi: 10.1182/blood.V87.10.4109.bloodjournal87104109
Park, J.-E. et al. A cell atlas of human thymic development defines T cell repertoire formation. Science 367, eaay3224 (2020).
doi: 10.1126/science.aay3224
Popescu, D.-M. et al. Decoding human fetal liver haematopoiesis. Nature 574, 365–371 (2019).
doi: 10.1038/s41586-019-1652-y
Wiemels, J. L. et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet 354, 1499–1503 (1999).
doi: 10.1016/S0140-6736(99)09403-9
Muntean, A. G., Ge, Y., Taub, J. W. & Crispino, J. D. Transcription factor GATA-1 and Down syndrome leukemogenesis. Leuk. Lymphoma 47, 986–997 (2006).
doi: 10.1080/10428190500485810
Roy, A. et al. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc. Natl Acad. Sci. USA 109, 17579–17584 (2012).
doi: 10.1073/pnas.1211405109
Olsson, A. et al. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Exp. Hematol. 44, S24 (2016).
doi: 10.1016/j.exphem.2016.06.010
Dahl, R. et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor. Nat. Immunol. 4, 1029–1036 (2003).
doi: 10.1038/ni973
Villani, A.-C. et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science 356, eaah4573 (2017).
doi: 10.1126/science.aah4573
Mullighan, C. G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446, 758–764 (2007).
doi: 10.1038/nature05690
Summers, Y. J., Heyworth, C. M., de Wynter, E. A., Chang, J. & Testa, N. G. Cord blood G
doi: 10.1634/stemcells.19-6-505
Pimanda, J. E. et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc. Natl Acad. Sci. USA 104, 17692–17697 (2007).
doi: 10.1073/pnas.0707045104
Iwasaki, H. et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106, 1590–1600 (2005).
doi: 10.1182/blood-2005-03-0860
Palii, C. G. et al. Single-cell proteomics reveal that quantitative changes in co-expressed lineage-specific transcription factors determine cell fate. Cell Stem Cell 24, 812–820 (2019).
doi: 10.1016/j.stem.2019.02.006
Muskens, I. S. et al. The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. Nat. Commun. 12, 821 (2021).
doi: 10.1038/s41467-021-21064-z
Yu, S. et al. GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood 117, 2166–2178 (2011).
doi: 10.1182/blood-2010-09-306563
Sullivan, K. D. et al. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation. Sci. Rep. 7, 14818 (2017).
doi: 10.1038/s41598-017-13858-3
Baccin, C. et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nat. Cell Biol. 22, 38–48 (2020).
doi: 10.1038/s41556-019-0439-6
Suchting, S. et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl Acad. Sci. USA 104, 3225–3230 (2007).
doi: 10.1073/pnas.0611177104
Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507, 323–328 (2014).
doi: 10.1038/nature13145
Itkin, T. et al. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature 532, 323–328 (2016).
doi: 10.1038/nature17624
Long, M. W., Briddell, R., Walter, A. W., Bruno, E. & Hoffman, R. Human hematopoietic stem cell adherence to cytokines and matrix molecules. J. Clin. Invest. 90, 251–255 (1992).
doi: 10.1172/JCI115844
Lane, W. J. et al. Stromal-derived factor 1–induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood 96, 4152–4159 (2000).
doi: 10.1182/blood.V96.13.4152
Schulz-Knappe, P. et al. HCC-1, a novel chemokine from human plasma. J. Exp. Med. 183, 295–299 (1996).
doi: 10.1084/jem.183.1.295
Butko, E., Pouget, C. & Traver, D. Complex regulation of HSC emergence by the Notch signaling pathway. Dev. Biol. 409, 129–138 (2016).
doi: 10.1016/j.ydbio.2015.11.008
Mulè, M. P., Martins, A. J. & Tsang, J. S. Normalizing and denoising protein expression data from droplet-based single cell profiling. Preprint at https://doi.org/10.1101/2020.02.24.96360 (2021).